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Université de Fribourg

Dynamic laser speckle imaging of cerebral blood flow

Zakharov, Pavel ; Völker, A. C. ; Wyss, M. T. ; Haiss, F. ; Calcinaghi, N. ; Zunzunegui, C. ; Buck, Alfred ; Scheffold, Frank ; Weber, Bruno

In: Optics Express, 2009, vol. 17, no. 16, p. 13904-13917

Laser speckle imaging (LSI) based on the speckle contrast analysis is a simple and robust technique for imaging of heterogeneous dynamics. LSI finds frequent application for dynamical mapping of cerebral blood flow, as it features high spatial and temporal resolution. However, the quantitative interpretation of the acquired data is not straightforward for the common case of a speckle field formed...

Université de Fribourg

The thalamocortical projection systems in Primate : an anatomical support for multisensory and sensorimotor interplay

Cappe, Céline ; Morel, Anne ; Barone, Pascal ; Rouiller, Eric M.

In: Cerebral Cortex, 2009, vol. 19, no. 9, p. 2025-2037

Multisensory and sensorimotor integrations are usually considered to occur in superior colliculus and cerebral cortex, but few studies proposed the thalamus as being involved in these integrative processes. We investigated whether the organization of the thalamocortical (TC) systems for different modalities partly overlap, representing an anatomical support for multisensory and sensorimotor...

Université de Fribourg

Dissociated lateralization of transient and sustained blood oxygen level-dependent signal components in human primary auditory cortex

Lehmann, Christoph ; Herdener, Marcus ; Schneider, Peter ; Federspiel, Andrea ; Bach, Dominik R. ; Esposito, Fabrizio ; di Salle, Francesco ; Scheffler, Klaus ; Kretz, Robert ; Dierks, Thomas ; Seifritz, Erich

In: NeuroImage, 2007, vol. 34, no. 4, p. 1637-1642

Among other auditory operations, the analysis of different sound levels received at both ears is fundamental for the localization of a sound source. These so-called interaural level differences, in animals, are coded by excitatory–inhibitory neurons yielding asymmetric hemispheric activity patterns with acoustic stimuli having maximal interaural level differences. In human auditory cortex, the...

Université de Fribourg

Direct comparison between properties of adaptation of the auditory nerve and the ventral cochlear nucleus in response to repetitive clicks

Meyer, Kaspar ; Rouiller, Eric M. ; Loquet, Gérard

In: Hearing Research, 2007, vol. 228, no. 1-2, p. 144-155

The present study was designed to complete two previous reports [Loquet, G., Rouiller, E.M., 2002. Neural adaptation to pulsatile acoustical stimulation in the cochlear nucleus of the rat. Hear. Res. 171, 72–81; Loquet, G., Meyer, K., Rouiller, E.M., 2003. Effects of intensity of repetitive acoustic stimuli on neural adaptation in the ventral cochlear nucleus of the rat. Exp. Brain Res. 153,...

Université de Fribourg

Développement d'un modèle expérimental d'implant cochléaire incorporant des propriétés d'adaptation neuronale

Loquet, Gérard ; Rouiller, Eric M. (Dir.)

Thèse de doctorat : Université de Fribourg, 2006.

The research projects reported in the present thesis deal with the auditory function and more specifically the topic dedicated to auditory rehabilitation with a prosthesis implanted into the cochlea: the cochlear implant (CI). Such prosthesis was used for about twenty years and already provides to numerous patients satisfactory conditions, excepted in noisy environment. From the point of view to...

Université de Fribourg

On the incidence of debris flows from the early Little Ice Age to a future greenhouse climate: A case study from the Swiss Alps

Stoffel, Markus ; Beniston, Martin

In: Geophysical Research Letters, 2006, vol. 33, p. L16404

Tree-ring based reconstructions of 123 debris-flow events in a case-study area of the Swiss Alps since AD 1570 show enhanced activity during the wet periods (1864–1895) following the last LIA glacier advance and in the early decades of the 20th century. In contrast, comparably low activity can be observed since 1995, with only one event recorded. From the reconstructions and based on RCM...

Université de Fribourg

Synaptic influences of pontine nuclei on cochlear nucleus cells

Babalian, Alexander L.

In: Experimental Brain Research, 2006, vol. 167, no. 3, p. 451-457

Using the in vitro isolated whole brain preparation of the guinea pig, we tested the synaptic effects induced by the stimulation of pontine nuclei (PN) in intracellularly recorded and stained principal cells of the cochlear nucleus (CN). Twenty percent of the recorded cells in all CN subdivisions responded to stimulation of either ipsilateral or contralateral PN, and 12% of the cells...

Université de Fribourg

Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis

Meli, Damian N. ; Coimbra, Roney S. ; Erhart, Dominik G. ; Loquet, Gérard ; Bellac, Caroline L. ; Täuber, Martin G. ; Neumann, Ulf ; Leib, Stephen L.

In: Infection and Immunity, 2006, vol. 74, no. 7, p. 3890-3896

Bacterial meningitis is characterized by an inflammatory reaction to the invading pathogens that can ultimately lead to sensorineural hearing loss, permanent brain injury, or death. The matrix metalloproteinases (MMPs) and tumor necrosis factor alpha-converting enzyme (TACE) are key mediators that promote inflammation, blood-brain barrier disruption, and brain injury in bacterial meningitis....

Université de Fribourg

The dual pattern of corticothalamic projection of the primary auditory cortex in macaque monkey

Rouiller, Eric M. ; Durif, Caroline

In: Neuroscience Letters, 2004, vol. 358, no. 1, p. 49-52

The distribution and terminal morphology of the corticothalamic projection originating from the primary auditory cortex (A1) were established in a macaque monkey, using the anterograde (and retrograde) tracer biotinylated dextran amine. A dense corticothalamic projection from A1 was found in the ventral (vMGB) and dorsal (dMGB) divisions of the medial geniculate body and, to a lesser extent,...