In: Brain Structure and Function, 2019, vol. 224, no. 1, p. 293–314
Although connections between the orbitofrontal cortex (OFC)—the seat of high cognitive functions—the lateral hypothalamus and the periaqueductal grey (PAG) have been recognized in the past, the precise targets of the descending fibres have not been identified. In the present study, viral tracer-transport experiments revealed neurons of the lateral (LO) and the ventrolateral (VLO) OFC...
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In: European Journal of Nuclear Medicine and Molecular Imaging, 2006, vol. 33, no. 11, p. 1301-1313
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In: Experimental Brain Research, 2003, vol. 153, no. 4, p. 452-460
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In: Brain : a journal of neurology, 1997, vol. 120, no. 12, p. 2187-2195
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In: Brain, 1996, vol. 119, no. 6, p. 2085-2095
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In: Human Molecular Genetics, 2008, vol. 17, no. 14, p. 2071-2083
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In: European Journal of Nuclear Medicine and Molecular Imaging, 2016, vol. 43, no. 3, p. 509–516
Purpose: To assess correlations between the degree of dopaminergic depletion measured using single-photon emission computed tomography (SPECT) and different clinical parameters of disease progression in Parkinson’s disease (PD).Methods: This retrospective study included 970 consecutive patients undergoing ¹²³I-ioflupane SPECT scans in our institution between 2003 and 2013, from which we...
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In: The International Journal of Neuropsychopharmacology, 2010, p. -
Dysfunction of brain dopamine transporter (DAT) has been associated with sensation seeking and impulse-control disorders. We recently generated a new animal model by stereotaxical inoculation of lentiviral vectors, which allowed localized intra-accumbal delivery of modulators for DAT gene: GFP (green fluorescent protein) control, silencers (Sil), a regulatable enhancer (DAT+), or both (DAT+Sil)....
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In: Neuroscience, 2009, vol. 159, no. 1, p. 47-58
Multiple theories have been proposed for sensation seeking and vulnerability to impulse-control disorders [Zuckerman M, Kuhlman DM (2000) Personality and risk-taking: Common biosocial factors. J Pers 68:999–1029], and many of these rely on a dopamine system deficit. Available animal models reproduce only some behavioral symptoms and seem devoid of construct validity. We used lentivirus tools...
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In: Genes, Brain and Behavior, 2008, vol. 7, no. 2, p. 244 - 256
Urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) are extracellular proteases that play a role in synaptic plasticity and remodeling. Psychostimulants induce both tPA and uPA in acute and chronic drug delivery, but cocaine induces preferentially uPA, whereas morphine and amphetamine induce preferentially tPA. Specific doxycline-regulatable lentiviruses...
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