In: Psychological Medicine, 2014, vol. 44, no. 5, p. 1015-1028
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In: Human Molecular Genetics, 2007, vol. 16, no. 6, p. 651-666
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In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1984, vol. 11, no. S1, p. 118-123
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In: Human Molecular Genetics, 2008, vol. 17, no. 14, p. 2071-2083
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In: Parkinsonism & Related Disorders, 2016, vol. 31, p. 53–58
123I-ioflupane SPECT is a powerful method to assess nigrostriatal dopamine system integrity. Several independent studies have shown that 1–15% of patients with suspected degenerative parkinsonism, mainly PD, have scans without evidence of dopaminergic deficit (SWEDD). It has been proposed that most SWEDD patients either present with a non-degenerative condition mimicking PD, such as...
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In: Behavioural Brain Research, 2016, vol. 298, Part B, p. 167–180
The parvafox nucleus is located ventrolaterally in the lateral hypothalamic area (LHA). Its core and shell are composed of neurons expressing the calcium-binding protein parvalbumin (PV) and the transcription factor Foxb1, respectively. Given the known functions of the LHA and that the parvafox nucleus receives afferents from the lateral orbitofrontal cortex and projects to the periaqueductal...
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In: Neuropharmacology, 2015, vol. 89, p. 398–411
Microdialysis during i.v. drug self-administration (SA) have implicated nucleus accumbens (NAc) shell DA in cocaine and heroin reinforcement. However, this correlative evidence has not been yet substantiated by experimental evidence obtained by studying the effect of selective manipulation of NAc shell DA transmission on cocaine and heroin SA. In order to investigate this issue, DA D1a receptor...
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In: Alcoholism: Clinical and Experimental Research, 2014, vol. 38, no. 9, p. 2369–2376
Background: It has been reported that dopamine D3 receptor (D3R) knockout mice display similar ethanol (EtOH) consumption compared to wild types. In addition, studies with D3R pharmacological targeting were inconclusive.Methods: In the current study, we used both gain- and loss-of-function approaches to test the effects of central D3R manipulation on voluntary alcohol intake and EtOH-induced...
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In: Neuroscience Letters, 2014, vol. 571, p. 29–33
This study reports for the first time the extracellular activity recorded, in anesthetized rats, from cells located in an identified cluster of parvalbumin (PV)-positive neurons of the lateral hypothalamus forming the PV1-nucleus. Random-like firing characterized the majority (21/30) of the cells, termed regular cells, with a median firing rate of 1.7 spikes/s, Fano factor equal to 1, and evenly...
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In: Neuroscience Letters, 2013, vol. 548, p. 38–43
Brain serotonin (5-HT) systems modulate emotional, motivational and cognitive processes. Mutations in the serotonin transporter (SERT) gene have been associated with susceptibility towards the development of several psychiatric disorders, both in humans and animal models. Present approach exploited a bilateral intra-hippocampus stereotaxic inoculation of lentiviruses, for enduring in vivo...
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