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Tumor-targeting properties of novel immunocytokines based on murine IL1β and IL6

Hess, Christian ; Neri, Dario

In: Protein Engineering, Design & Selection, 2014, vol. 27, no. 6, p. 207-213

Université de Fribourg

Osteology, fossil record and palaeodiversity of the European lizards

Villa, Andrea ; Tschopp, Emanuel ; Georgalis, Georgios L. ; Delfino, Massimo

In: Amphibia-Reptilia, 2017, vol. 38, no. 1, p. 79–88

he capability of palaeontologists to identify fossil remains of a particular group of vertebrates strongly depends on the knowledge they have of its comparative osteology and on the actual presence of diagnostic differences among the considered taxa. This could have a relevant influence on the study of palaeodiversity, since a low recognisability causes a loss of data when trying to...

Université de Fribourg

Mature lipid droplets are accessible to ER luminal proteins

Mishra, Shirish ; Khaddaj, Rasha ; Cottier, Stéphanie ; Stradalova, Vendula ; Jacob, Claire ; Schneiter, Roger

In: Journal of Cell Science, 2016, vol. 129, no. 20, p. 3803–3815

Lipid droplets are found in most organisms where they serve to store energy in the form of neutral lipids. They are formed at the endoplasmic reticulum (ER) membrane where the neutral-lipid-synthesizing enzymes are located. Recent results indicate that lipid droplets remain functionally connected to the ER membrane in yeast and mammalian cells to allow the exchange of both lipids and integral...

Université de Fribourg

The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits

Fernández-Pevida, Antonio ; Martín-Villanueva, Sara ; Murat, Guillaume ; Lacombe, Thierry ; Kressler, Dieter ; Cruz, Jesús de la

In: Nucleic Acids Research, 2016, vol. 44, no. 16, p. 7777–7791

The archaea-/eukaryote-specific 40S-ribosomal-subunit protein S31 is expressed as an ubiquitin fusion protein in eukaryotes and consists of a conserved body and a eukaryote-specific N-terminal extension. In yeast, S31 is a practically essential protein, which is required for cytoplasmic 20S pre-rRNA maturation. Here, we have studied the role of the N-terminal extension of the yeast S31...

Université de Fribourg

Heme oxygenase-1/carbon monoxide system and embryonic stem cell differentiation and maturation into cardiomyocytes

Suliman, Hagir B. ; Zobi, Fabio ; Piantadosi, Claude A.

In: Antioxidants & Redox Signaling, 2016, vol. 24, no. 7, p. 345–360

The differentiation of embryonic stem (ES) cells into energetically efficient cardiomyocytes contributes to functional cardiac repair and is envisioned to ameliorate progressive degenerative cardiac diseases. Advanced cell maturation strategies are therefore needed to create abundant mature cardiomyocytes. In this study, we tested whether the redox-sensitive heme oxygenase-1/carbon monoxide...

Université de Fribourg

The multiplicity of alternative splicing decisions in Caenorhabditis elegans is linked to specific intronic regulatory motifs and minisatellites

Glauser, Dominique A.

In: BMC Genomics, 2014, vol. 15, no. 1, p. 364

Background: alternative splicing diversifies the pool of messenger RNA molecules encoded by individual genes. This diversity is particularly high when multiple splicing decisions cause a combinatorial arrangement of several alternate exons. We know very little on how the multiple decisions occurring during the maturation of single transcripts are coordinated and whether specific sequence elements...