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Université de Fribourg

Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo

Sully, Erin K. ; Geller, Bruce L. ; Li, Lixin ; Moody, Christina M. ; Bailey, Stacey M. ; Moore, Amy L. ; Wong, Michael ; Nordmann, Patrice ; Daly, Seth M. ; Sturge, Carolyn R. ; Greenberg, David E.

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 3, p. 782–790

The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.Methods: We have constructed a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that selectively inhibits...

Université de Fribourg

Origin of micropores In late jurassic (Oxfordian) micrites of the eastern Paris basin, France

Carpentier, Cédric ; Ferry, Serge ; Lécuyer, Christophe ; Strasser, André ; Géraud, Yves ; Trouiller, Alain

In: Journal of Sedimentary Research, 2015, vol. 85, no. 6, p. 660–682

Porous micritic facies, either primary chalks or resulting from secondary destructive micritization, can constitute important hydrocarbon or water reservoirs. Characterization of reservoir properties and the understanding of factors which controlled the distribution of porosity are of primary interest to evaluate the prospective reserves. Middle and late Oxfordian limestones of the eastern Paris...

Université de Fribourg

Contribution to the understanding of the Ionian Basin sedimentary evolution along the eastern edge of Apulia during the Late Cretaceous in Albania

Le Goff, J. ; Cerepi, A. ; Swennen, R. ; Loisy, C. ; Caron, Michèle ; Muska, K. ; Desouky, H. El

In: Sedimentary Geology, 2015, vol. 317, p. 87–101

Integrated in the peri-Adriatic domain, the Ionian Basin extended along a NW-SE direction during the Late Cretaceous, limited on its sides by the Apulian and the Kruja platforms. The basinal/slope succession was studied in seven outcrops exposed in the Albanian fold-and-thrust belt. Sedimentological investigations, supported by bio- and chronostratigraphy were performed on calcareous Upper...

Université de Fribourg

Information filtering in sparse online systems: recommendation via semi-local diffusion

Zeng, Wei ; Zeng, An ; Shang, Ming-Sheng ; Zhang, Yi-Cheng

In: PLoS ONE, 2013, vol. 8, no. 11, p. e79354

With the rapid growth of the Internet and overwhelming amount of information and choices that people are confronted with, recommender systems have been developed to effectively support users’ decision-making process in the online systems. However, many recommendation algorithms suffer from the data sparsity problem, i.e. the user-object bipartite networks are so sparse that algorithms cannot...

Université de Fribourg

Glacier and runoff changes in the Rukhk catchment, upper Amu-Darya basin until 2050

Hagg, Wilfried ; Hoelzle, Martin ; Wagner, Stephan ; Mayr, Elisabeth ; Klose, Zbynek

In: Global and Planetary Change, 2013, vol. 110, Part A, p. 62–73

A conceptual hydrological model was set up in the upper Panj catchment, the main tributary of Amu-Darya river. After a manual calibration procedure involving model runs with different restrictions, the model reproduced both daily hydrographs of Tanimas river at the Rukhk gauging station (NSE = 0.86) and the snow water equivalent of the Irkht station (R2 = 0.85) in a very satisfactory way. Based...