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Università della Svizzera italiana

On multicast primitives in large networks and partial replication protocols

Schiper, Nicolas ; Pedone, Fernando (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2009 ; 2009INFO005.

Recent years have seen the rapid growth of web-based applications such as search engines, social networks, and e-commerce platforms. As a consequence, our daily life activities rely on computers more and more each day. Designing reliable computer systems has thus become of a prime importance. Reliability alone is not sufficient however. These systems must support high loads of client...

Università della Svizzera italiana

On non-intrusive workload-aware database replication

Narváez, Vaide ; Pedone, Fernando (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2009 ; 2009INFO002.

Performance and high-availability are the crucial factors in the development of nowadays distributed database systems. Both of these challenges are commonly addressed by means of the same technique, database replication. The overall throughput of the system is increased by leveraging parallel computation on different sites, and in case of replica failures, availability is improved by...

Université de Fribourg

Density dependent interactions and structure of charged colloidal dispersions in the weak screening regime

Rojas-Ochoa, Luis Fernando ; Castañeda-Priego, R. ; Lobaskin, V. ; Stradner, Anna ; Scheffold, Frank ; Schurtenberger, Peter

In: Physical Review Letters, 2008, vol. 100, p. 178304

We determine the structure of charge-stabilized colloidal suspensions at low ionic strength over an extended range of particle volume fractions using a combination of light and small angle neutron scattering experiments. The variation of the structure factor with concentration is analyzed within a one-component model of a colloidal suspension. We show that the observed structural behavior...

Université de Fribourg

Bax function in the absence of mitochondria in the primitive protozoan Giardia lamblia

Hehl, Adrian B. ; Regos, Attila ; Schraner, Elisabeth ; Schneider, André

In: PLoS ONE, 2007, vol. 2, no. 5, p. e488

Bax-induced permeabilization of the mitochondrial outer membrane and release of cytochrome c are key events in apoptosis. Although Bax can compromise mitochondria in primitive unicellular organisms that lack a classical apoptotic machinery, it is still unclear if Bax alone is sufficient for this, or whether additional mitochondrial components are required. The protozoan parasite Giardia lamblia...