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Université de Fribourg

Increased temperature disrupts the biodiversity–ecosystem functioning relationship

Parain, Elodie C. ; Rohr, Rudolf P. ; Gray, Sarah M. ; Bersier, Louis-Félix

In: The American Naturalist, 2018, vol. 193, no. 2, p. 227–239

Gaining knowledge of how ecosystems provide essential services to humans is of primary importance, especially with the current threat of climate change. Yet little is known about how increased temperature will impact the biodiversity–ecosystem functioning (BEF) relationship. We tackled this subject theoretically and experimentally. We developed a BEF theory based on mechanistic population ...

Università della Svizzera italiana

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

Willinger, Tim ; Rongvaux, Anthony ; Takizawa, Hitoshi ; Yancopoulos, George D. ; Valenzuela, David M. ; Murphy, Andrew J. ; Auerbach, Wojtek ; Eynon, Elizabeth E. ; Stevens, Sean ; Manz, Markus G. ; Flavell, Richard A.

In: Proceedings of the national academy of sciences of the United States of America, 2011, vol. 108, no. 6, p. 2390-2395

Mice with a functional human immune system have the potential to allow in vivo studies of human infectious diseases and to enable vaccine testing. To this end, mice need to fully support the development of human immune cells, allow infection with human pathogens, and be capable of mounting effective human immune responses. A major limitation of humanized mice is the poor development and...

Università della Svizzera italiana

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

Rongvaux, Anthony ; Willinger, Tim ; Takizawa, Hitoshi ; Rathinam, Chozhavendan ; Auerbach, Wojtek ; Murphy, Andrew J. ; Valenzuela, David M. ; Yancopoulos, George D. ; Eynon, Elizabeth E. ; Stevens, Sean ; Manz, Markus G. ; Flavell, Richard A.

In: Proceedings of the national academy of sciences of the United States of America, 2011, vol. 108, no. 6, p. 2378-2383

Hematopoietic stem cells (HSCs) both self-renew and give rise to all blood cells for the lifetime of an individual. Xenogeneic mouse models are broadly used to study human hematopoietic stem and progenitor cell biology in vivo. However, maintenance, differentiation, and function of human hematopoietic cells are suboptimal in these hosts. Thrombopoietin (TPO) has been demonstrated as a crucial...

Université de Fribourg

Global glacier volume projections under high-end climate change scenarios

Shannon, Sarah ; Smith, Robin ; Wiltshire, Andy ; Payne, Tony ; Huss, Matthias ; Betts, Richard ; Caesar, John ; Koutroulis, Aris ; Jones, Darren ; Harrison, Stephan

In: The Cryosphere, 2019, vol. 13, no. 1, p. 325–350

The Paris agreement aims to hold global warming to well below 2 ∘C and to pursue efforts to limit it to 1.5 ∘C relative to the pre-industrial period. Recent estimates based on population growth and intended carbon emissions from participant countries suggest global warming may exceed this ambitious target. Here we present glacier volume projections for the end of this century, under a...

Université de Fribourg

Cyclostratigraphy of shallow-marine carbonates – limitations and opportunities

Strasser, André

In: Stratigraphy & Timescales, 2018, vol. 3, p. 151–187

The sedimentary record of ancient shallow-marine carbonate platforms commonly displays a stacking of different facies, which reflects repetitive changes of depositional environments through time. These changes can be induced by external factors such as cyclical changes in climate and/or sea level, but also by internal factors such as lateral migration of sediment bodies and/or changes in the...

Université de Fribourg

A gardener’s influence on urban soil quality

Tresch, Simon ; Moretti, Marco ; Le Bayon, Renée-Claire ; Mäder, Paul ; Zanetta, Andrea ; Frey, David ; Fliessbach, Andreas

In: Frontiers in Environmental Science, 2018, vol. 6, p. -

Gardens are hot spots for urban biodiversity and provide habitats for many plant and animal species, both above- and below-ground. Furthermore, gardens provide a wide range of ecosystem services, including carbon (C) storage and nutrient cycling. Although the soil is the foundation of sustainable gardens providing those ecosystem services, very little is known about the consequences of garden...

Haute école de gestion de Genève

Investing in Asian frontier markets : is the risk worth the return?

Marchon, Cindy ; Ruiz, Frédéric (Dir.)

Mémoire de bachelor : Haute école de gestion de Genève, 2018 ; TDIBM 40.

Frontier markets are gaining in popularity in the investment world, as they present the advantage of high returns with potentially diminishing risks in the future and attractive correlation characteristics as globalization unfolds. As the growth of China has slowed down in the past few years, Asian frontier markets are the countries investors turn to expecting rapid economic growth. However,...

Université de Fribourg

A snow density dataset for improving surface boundary conditions in greenland ice sheet firn modeling

Fausto, Robert S. ; Box, Jason E. ; Vandecrux, Baptiste ; As, Dirk van ; Steffen, Konrad ; MacFerrin, Michael J. ; Machguth, Horst ; Colgan, William ; Koenig, Lora S. ; McGrath, Daniel ; Charalampidis, Charalampos ; Braithwaite, Roger J.

In: Frontiers in Earth Science, 2018, vol. 6, p. -

The surface snow density of glaciers and ice sheets is of fundamental importance in converting volume to mass in both altimetry and surface mass balance studies, yet it is often poorly constrained. Site-specific surface snow densities are typically derived from empirical relations based on temperature and wind speed. These parameterizations commonly calculate the average density of the top...