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Université de Fribourg

V1-bypassing thalamo-cortical visual circuits in blindsight and developmental dyslexia

Rima, Samy ; Schmid, Michael Christoph

In: Current Opinion in Physiology, 2020, vol. 16, p. 14–20

Vision rests on computations that primarily rely on the parvocellular and magnocellular geniculate relay of retinal signals to V1. Secondary pathways involving superior colliculus, koniocellular lateral geniculate nucleus and pulvinar and their V1-bypassing projections to higher order cortex are known to exist. While they may form an evolutionary old visual system, their contribution to...

Université de Fribourg

Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor

Bahi, Amine ; Dreyer, Jean-Luc

In: European Neuropsychopharmacology, 2020, vol. 37, p. 70–81

Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. However, the exact role of let-7d miRNA in regulating ethanol intake and preference remains to be elucidated. The aim of the present study was to clarify the role of accumbal let-7d in controlling...

Université de Fribourg

Scientists’ warning on invasive alien species

Pyšek, Petr ; Hulme, Philip E. ; Simberloff, Dan ; Bacher, Sven ; Blackburn, Tim M. ; Carlton, James T. ; Dawson, Wayne ; Essl, Franz ; Foxcroft, Llewellyn C. ; Genovesi, Piero ; Jeschke, Jonathan M. ; Kühn, Ingolf ; Liebhold, Andrew M. ; Mandrak, Nicholas E. ; Meyerson, Laura A. ; Pauchard, Aníbal ; Pergl, Jan ; Roy, Helen E. ; Seebens, Hanno ; Kleunen, Mark ; Vilà, Montserrat ; Wingfield, Michael J. ; Richardson, David M.

In: Biological Reviews, 2020, p. brv.12627

Biological invasions are a global consequence of an increasingly connected world and the rise in human population size. The numbers of invasive alien species – the subset of alien species that spread widely in areas where they are not native, affecting the environment or human livelihoods – are increasing. Synergies with other global changes are exacerbating current invasions and...

Université de Fribourg

Measurement of ultra-trace level of intact oxytocin in plasma using SALLE combined with nano-LC–MS

Liu, Dan ; Han, Xiaoli ; Liu, Xinxin ; Cheng, Mengchun ; He, Meixi ; Rainer, Gregor ; Gao, Huiyuan ; Zhang, Xiaozhe

In: Journal of Pharmaceutical and Biomedical Analysis, 2019, vol. 173, p. 62–67

Measurement of peptides such as oxytocin in plasma is a critical challenge in clinical research because of their extreme low concentrations as well as the tremendous interferencing substances co-presented in plasma. In this study, we developed an efficient salt-out assisted liquid-liquid extraction (SALLE) to treat plasma, and then analyzed the samples using nano-LC–MS to quantify intact...

Université de Fribourg

The orbitofrontal cortex projects to the parvafox nucleus of the ventrolateral hypothalamus and to its targets in the ventromedial periaqueductal grey matter

Babalian, Alexandre ; Eichenberger, Simone ; Bilella, Alessandro ; Girard, Franck ; Szabolcsi, Viktoria ; Roccaro, Diana ; Alvarez-Bolado, Gonzalo ; Xu, Chun ; Celio, Marco R.

In: Brain Structure and Function, 2019, vol. 224, no. 1, p. 293–314

Although connections between the orbitofrontal cortex (OFC)—the seat of high cognitive functions—the lateral hypothalamus and the periaqueductal grey (PAG) have been recognized in the past, the precise targets of the descending fibres have not been identified. In the present study, viral tracer-transport experiments revealed neurons of the lateral (LO) and the ventrolateral (VLO) OFC...

Université de Fribourg

Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice

Bahi, Amine ; Dreyer, Jean-Luc

In: Behavioural Brain Research, 2019, vol. 359, p. 104–115

Many epidemiological and clinical studies have demonstrated a strong comorbidity between anxiety and depression, and a number of experimental studies indicates that the dopamine transporter (DAT) is involved in the pathophysiology of anxiety and depression. However, studies using laboratory animals have yielded inconclusive results. The aim of the present study was to examine the effects of...