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Università della Svizzera italiana

Isonitrile-based multicomponent synthesis of β-amino boronic acids as β-lactamase inhibitors

Bassini, Emanuele ; Gazzotti, Stefano ; Sannio, Filomena ; Lo Presti, Leonardo ; Sgrignani, Jacopo ; Docquier, Jean-Denis ; Grazioso, Giovanni ; Silvani, Alessandra

In: Antibiotics, 2020, vol. 9, no. 5, p. 21 p

The application of various isonitrile-based multicomponent reactions to protected (2-oxoethyl)boronic acid (as the carbonyl component) is described. The Ugi reaction, both in the four components and in the four centers–three components versions, and the van Leusen reaction, proved effective at providing small libraries of MIDA-protected β-aminoboronic acids. The corresponding free...

Università della Svizzera italiana

Coating and functionalization strategies for nanogels and nanoparticles for selective drug delivery

Pinelli, Filippo ; Giuseppe Perale ; Filippo Rossi

In: Gels, 2020, vol. 6, no. 1, p. 6

Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be...

Università della Svizzera italiana

Oxidation state dependent conformational changes of HMGB1 regulate the formation of the CXCL12/HMGB1 heterocomplex

Fassi, Enrico M.A. ; Sgrignani, Jacopo ; D'Agostino, Gianluca ; Cecchinato, Valentina ; Garofalo, Maura ; Grazioso, Giovanni ; Uguccioni, Mariagrazia ; Cavalli, Andrea

In: Computational and structural biotechnology journal, 2019, vol. 17, p. 886-894

High-mobility Group Box 1 (HMGB1) is an abundant protein present in all mammalian cells and involved in several processes. During inflammation or tissue damage, HMGB1 is released in the extracellular space and, depending on its redox state, can form a heterocomplex with CXCL12. The heterocomplex acts exclusively via the chemokine receptor CXCR4 enhancing leukocyte recruitment. Here, we used...

Consortium of Swiss Academic Libraries

Disjunctive programming and relaxations of polyhedra

Conforti, Michele ; Del Pia, Alberto

In: Mathematical Programming, 2014, vol. 144, no. 1-2, p. 307-314

Université de Fribourg

Nonequilibrium solid-solid phase transition in a lattice of liquid jets

Croccolo, Fabrizio ; Castellini, Stefano ; Scheffold, Frank ; Vailati, Alberto

In: Physical Review E, 2018, vol. 98, no. 6, p. 063104

Solid-solid phase transitions are commonly encountered at the atomic scale in alloys and in superatomic mesoscopic systems of colloidal particles. Here we investigate a solid-solid phase transition occurring at the macroscopic scale between lattices of liquid jets with different symmetries generated by convection in a horizontal layer of a binary liquid mixture. In the absence of a shear...

Consortium of Swiss Academic Libraries

Isoperimetric inequality in the Grushin plane

Monti, Roberto ; Morbidelli, Daniele

In: The Journal of Geometric Analysis, 2004, vol. 14, no. 2, p. 355-368

Consortium of Swiss Academic Libraries

Monte Carlo Simulations of Vesicles and Fluid Membranes Transformations

Piotto, Stefano ; Mavelli, Fabio

In: Origins of life and evolution of the biosphere, 2004, vol. 34, no. 1-2, p. 225-235