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Conserved functions of ether lipids and sphingolipids in the early secretory pathway

Jiménez-Rojo, Noemi ; Leonetti, Manuel D. ; Zoni, Valeria ; Colom, Adai ; Feng, Suihan ; Iyengar, Namrata R. ; Matile, Stefan ; Roux, Aurélien ; Vanni, Stefano ; Weissman, Jonathan S. ; Riezman, Howard

In: Current Biology, 2020, vol. 30, no. 19, p. 3775-3787.e7

Sphingolipids play important roles in physiology and cell biology, but a systematic examination of their functions is lacking. We performed a genome-wide CRISPRi screen in sphingolipid-depleted human cells and identified hypersensitive mutants in genes of membrane trafficking and lipid biosynthesis, including ether lipid synthesis. Systematic lipidomic analysis showed a coordinate regulation...

The yeast cell wall protein Pry3 inhibits mating through highly conserved residues within the CAP domain

Cottier, Stéphanie ; Darwiche, Rabih ; Meyenhofer, Felix ; Debelyy, Mykhaylo O. ; Schneiter, Roger

In: Biology Open, 2020, vol. 9, no. 6, p. bio053470

Members of the CAP/SCP/TAPS superfamily have been implicated in many different physiological processes, including pathogen defense, sperm maturation and fertilization. The mode of action of this class of proteins, however, remains poorly understood. The genome of Saccharomyces cerevisiae encodes three CAP superfamily members, Pry1-3. We have previously shown that Pry1 function is required...

Optimization of anchor nodes placement in wireless localization networks

Balac, Katarina ; Malek, Miroslaw (Dir.) ; Prevostini, Mauro (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO009.

This work focuses on optimizing node placement for time-of-flight-based wireless localization networks. Main motivation are critical safety applications. The first part of my thesis is an experimental study on in-tunnel vehicle localization. In- tunnel localization of vehicles is crucial for emergency management, especially for large trucks transporting dangerous goods such as inflammable...

How phosphorylation influences E1 subunit pyruvate dehydrogenase : A computational study

Sgrignani, Jacopo ; Chen, JingJing ; Alimonti, Andrea ; Cavalli, Andrea

In: Scientific reports, 2018, vol. 8, p. 14683

Pyruvate (PYR) dehydrogenase complex (PDC) is an enzymatic system that plays a crucial role in cellular metabolism as it controls the entry of carbon into the Krebs cycle. From a structural point of view, PDC is formed by three different subunits (E1, E2 and E3) capable of catalyzing the three reaction steps necessary for the full conversion of pyruvate to acetyl-CoA. Recent investigations...

Pathogens, toxins, and lipid rafts

Fivaz, M. ; Abrami, L. ; van der Goot, F.

In: Protoplasma, 2000, vol. 212, no. 1-2, p. 8-14

GPI anchor biosynthesis in yeast: phosphoethanolamine is attached to the α1,4-linked mannose of the complete precursor glycophospholipid

Canivenc-Gansel, Elisabeth ; Imhof, Isabella ; Reggiori, Fulvio ; Burda, Patricie ; Conzelmann, Andreas ; Benachour, Abdellah

In: Glycobiology, 1998, vol. 8, no. 8, p. 761-770

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits

Albert, Thomas K. ; Lemaire, Marc ; van Berkum, Nynke L. ; Gentz, Reiner ; Collart, Martine A. ; Timmers, H. Th. Marc

In: Nucleic Acids Research, 2000, vol. 28, no. 3, p. 809-817

Identification of GPI anchor attachment signals by a Kohonen self-organizing map

Fankhauser, Niklaus ; Mäser, Pascal

In: Bioinformatics, 2005, vol. 21, no. 9, p. 1846-1852

Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A

Schwer, Beate ; Linder, Patrick ; Shuman, Stewart

In: Nucleic Acids Research, 1998, vol. 26, no. 3, p. 803-809

The N-glycosylation defect of cwh8Δ yeast cells causes a distinct defect in sphingolipid biosynthesis

Pittet, Martine ; Uldry, Danièle ; Aebi, Markus ; Conzelmann, Andreas

In: Glycobiology, 2006, vol. 16, no. 2, p. 155-164