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Prolonged complete remission of metastatic HER2-positive breast cancer after continuous trastuzumab treatment: a case report and review of the literature

Ihnenfeld Arciénega, Isabel ; Imesch, Patrick ; Fink, Daniel ; Dedes, Konstantin

In: Targeted Oncology, 2015, vol. 10, no. 2, p. 297-301

Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer

Tschui, J. ; Vassella, E. ; Bandi, N. ; Baumgartner, U. ; Genitsch, V. ; Rotzer, D. ; Seiler, R. ; Thalmann, G. ; Fleischmann, A.

In: Virchows Archiv, 2015, vol. 466, no. 6, p. 703-710

Differential expression of epithelial-mesenchymal transition and stem cell markers in intrinsic subtypes of breast cancer

Pomp, Victoria

In: Breast Cancer Research and Treatment, ///-

Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer

Alday-Parejo, Begoña ; Richard, François ; Wörthmüller, Janine ; Rau, Tilman ; Galván, José A. ; Desmedt, Christine ; Santamaria-Martinez, Albert ; Rüegg, Curzio

In: Cancers, 2020, vol. 12, no. 1, p. 223

Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an intracellular adaptor protein that stabilizes epithelial junctions consistent with a tumor suppressive function in several cancers of epithelial origin. Here we report, based on experimental results and human breast cancer (BC) patients’ gene expression data, that MAGI1 is highly expressed and acts...

Detection of HER2+ breast cancer cells using bioinspired DNA-based signal amplification

Rafiee, Sarah D. ; Kocabey, Samet ; Mayer, Michael ; List, Jonathan ; Rüegg, Curzio

In: ChemMedChem, 2020, vol. 15, no. 8, p. 661-666

Circulating tumor cells (CTC) are promising biomarkers for metastatic cancer detection and monitoring progression. However, detection of CTCs remains challenging due to their low frequency and heterogeneity. Herein, we report a bioinspired approach to detect individual cancer cells, based on a signal amplification cascade using a programmable DNA hybridization chain reaction (HCR) circuit. We...

Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

Muenst, S. ; Schaerli, A. ; Gao, F. ; Däster, S. ; Trella, E. ; Droeser, R. ; Muraro, M. ; Zajac, P. ; Zanetti, R. ; Gillanders, W. ; Weber, W. ; Soysal, S.

In: Breast Cancer Research and Treatment, 2014, vol. 146, no. 1, p. 15-24

Expression analysis of heat shock protein 90 (HSP90) and Her2 in colon carcinoma

Drecoll, Enken ; Nitsche, Ulrich ; Bauer, Karina ; Berezowska, Sabina ; Slotta-Huspenina, Julia ; Rosenberg, Robert ; Langer, Rupert

In: International Journal of Colorectal Disease, 2014, vol. 29, no. 6, p. 663-671

VEGFA gene locus analysis across 80 human tumour types reveals gene amplification in several neoplastic entities

Andreozzi, Mariacarla ; Quagliata, Luca ; Gsponer, Joel ; Ruiz, Christian ; Vuaroqueaux, Vincent ; Eppenberger-Castori, Serenella ; Tornillo, Luigi ; Terracciano, Luigi

In: Angiogenesis, 2014, vol. 17, no. 3, p. 519-527

Biomarkers in renal cancer

Moch, Holger ; Srigley, John ; Delahunt, Brett ; Montironi, Rodolfo ; Egevad, Lars ; Tan, Puay

In: Virchows Archiv, 2014, vol. 464, no. 3, p. 359-365

A bio-inspired amplification cascade for the detection of rare cancer cells

Rüegg, Curzio ; Reis, Corine ; Rafiee, Sarah ; Rodriguez-Lorenzo, Laura ; List, Jonathan ; Rothen-Rutishauser, Barbara ; Mayer, Michael ; Petri-Fink, Alke

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 63–68

The main cause of cancer-related death is due to cancer cell spreading and formation of secondary tumors in distant organs, the so-called metastases. Metastatic cancer cells are detectable in the blood of cancer patients as circulating tumor cells (CTC) and may be exploited for prognostic and monitoring purposes, including in breast cancer. Due to their very low frequency, however, their...