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Université de Neuchâtel

Increasing the size of metalla-assemblies to target the EPR-effect of tumors and solid cancers

Mannancherril, Vidya ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

Cancer, a malignant disease, is one of the leading causes of mortality and morbidity among humans. However, selective targeting of cancerous tissue remains challenging. The enhanced permeability and retention effect (EPR-effect), a naturally occurring phenomenon in solid cancerous tissue, is a suitable treatment pathway to selectively target cancerous tissues, whereas healthy tissue remains...

Université de Neuchâtel

Hydrogen-bonded metalla-assemblies

Zhang, Fan ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Hydrogen bonds are the most utilized non-covalent interactions in biological systems, due to their directionality, stability, reversibility and diversity. The weak strength of hydrogen-bond can be modified by combining several hydrogen bonds in the same unit, like in the melamine∙cyanuric/barbituric acid rosette-type system. Arene ruthenium metalla-assemblies have showed a great biological...

Université de Fribourg

Novel iron tweezers complexes for hydrogenation and polymerization of olefins

Mafua, Roger ; Jenny, Titus A. (Dir.)

Thèse de doctorat : Université de Fribourg, 2006 ; no. 1503.

The use of organometallic complexes as catalysts became a very significant topic in the field of material chemistry. However, despite of this development, only few of them contain iron(II), except the tridentate complex diimine pyridine developed by Gibson and Brookhart and employed in the olefin polymerization. Unfortunately, this model suffers by its lack of tolerance towards the minor changes...