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Université de Fribourg

Skin proteomics – analysis of the extracellular matrix in health and disease

Dengjel, Jörn ; Bruckner-Tuderman, Leena ; Nyström, Alexander

In: Expert Review of Proteomics, 2020, vol. 17, no. 5, p. 377–391

Introduction The skin protects the human body from external insults and regulates water and temperature homeostasis. A highly developed extracellular matrix (ECM) supports the skin and instructs its cell functions. Reduced functionality of the ECM is often associated with skin diseases that cause physical impairment and also have implications on social interactions and quality of life of...

Université de Fribourg

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff, Irini M. ; Drasler, Barbara ; Karakocak, Bedia Begum ; Petri-Fink, Alke ; Valacchi, Giuseppe ; Eeman, Marc ; Rothen-Rutishauser, Barbara

In: Particle and Fibre Toxicology, 2020, vol. 17, no. 1, p. 35

Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution- associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles.Main text: To date, most of the research studies did focus on the...

Université de Fribourg

Population genomic analysis of elongated skulls reveals extensive female-biased immigration in Early Medieval Bavaria

Veeramah, Krishna R. ; Rott, Andreas ; Groß, Melanie ; Dorp, Lucy van ; López, Saioa ; Kirsanow, Karola ; Sell, Christian ; Blöcher, Jens ; Wegmann, Daniel ; Link, Vivian ; Hofmanová, Zuzana ; Peters, Joris ; Trautmann, Bernd ; Gairhos, Anja ; Haberstroh, Jochen ; Päffgen, Bernd ; Hellenthal, Garrett ; Haas-Gebhard, Brigitte ; Harbeck, Michaela ; Burger, Joachim

In: Proceedings of the National Academy of Sciences, 2018, p. 201719880

Modern European genetic structure demonstrates strong correlations with geography, while genetic analysis of prehistoric humans has indicated at least two major waves of immigration from outside the continent during periods of cultural change. However, population-level genome data that could shed light on the demographic processes occurring during the intervening periods have been absent....

Université de Fribourg

The oldest Archaeopteryx (Theropoda: Avialiae): a new specimen from the Kimmeridgian/Tithonian boundary of Schamhaupten, Bavaria

Rauhut​, Oliver W.M. ; Foth, Christian ; Tischlinger, Helmut

In: PeerJ, 2018, vol. 6, p. e4191

The iconic primeval bird Archaeopteryx was so far mainly known from the Altmühltal Formation (early Tithonian) of Bavaria, southern Germany, with one specimen having been found in the overlying Mörnsheim Formation. A new specimen (the 12th skeletal specimen) from the earliest Tithonian Painten Formation of Schamhaupten (Bavaria) represents the so far oldest representative of the genus. The...

Université de Fribourg

Re-evaluation of the Haarlem Archaeopteryx and the radiation of maniraptoran theropod dinosaurs

Foth, Christian ; Rauhut, Oliver W. M.

In: BMC Evolutionary Biology, 2017, vol. 17, p. 236

Archaeopteryx is an iconic fossil that has long been pivotal for our understanding of the origin of birds. Remains of this important taxon have only been found in the Late Jurassic lithographic limestones of Bavaria, Germany. Twelve skeletal specimens are reported so far. Archaeopteryx was long the only pre-Cretaceous paravian theropod known, but recent discoveries from the Tiaojishan...