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Université de Fribourg

Review of emerging japanese encephalitis virus: new aspects and concepts about entry into the brain and inter-cellular spreading

Filgueira, Luis ; Lannes, Nils

In: Pathogens, 2019, vol. 8, no. 3, p. 111

Japanese encephalitis virus (JEV) is an emerging flavivirus of the Asia-Pacific region. More than two billion people live in endemic or epidemic areas and are at risk of infection. Recently, the first autochthonous human case was recorded in Africa, and infected birds have been found in Europe. JEV may spread even further to other continents. The first section of this review covers...

Università della Svizzera italiana

When and how java developers give up static type safety

Mastrangelo, Luis ; Hauswirth, Matthias (Dir.) ; Nystrom, Nathaniel (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO008.

The main goal of a static type system is to prevent certain kinds of errors from happening at run time. A type system is formulated as a set of constraints that gives any expression or term in a program a well-defined type. Besides detecting these kinds of errors, a static type system can be an invaluable maintenance tool, can be useful for documentation purposes, and can aid in generating ...

Université de Fribourg

CX 3 CR1-CX 3 CL1-dependent cell-to-cell Japanese encephalitis virus transmission by human microglial cells

Lannes, Nils ; Garcia-Nicolàs, Obdullio ; Démoulins, Thomas ; Summerfield, Artur ; Filgueira, Luis

In: Scientific Reports, 2019, vol. 9, no. 1, p. 4833

The neurotropic Japanese encephalitis virus (JEV) is responsible for Japanese encephalitis, an uncontrolled inflammatory disease of the central nervous system. Microglia cells are the unique innate immune cell type populating the brain that cross- communicate with neurons via the CX3CR1-CX3CL1 axis. However, microglia may serve as a viral reservoir for JEV. Human microglia are able to transmit...

Université de Fribourg

Regulation of inflammation in Japanese encephalitis

Lannes, Nils ; Summerfield, Artur ; Filgueira, Luis

In: Journal of Neuroinflammation, 2017, vol. 14, p. 158

Uncontrolled inflammatory response of the central nervous system is a hallmark of severe Japanese encephalitis (JE). Although inflammation is necessary to mount an efficient immune response against virus infections, exacerbated inflammatory response is often detrimental. In this context, cells of the monocytic lineage appear to be important forces driving JE pathogenesis.

Consortium of Swiss Academic Libraries



In: Glasgow Mathematical Journal, 2012, vol. 54, no. 1, p. 61-66

Université de Fribourg

Interactions of human microglia cells with Japanese encephalitis virus

Lannes, Nils ; Neuhaus, Viviane ; Scolari, Brigitte ; Kharoubi-Hess, Solange ; Walch, Michael ; Summerfield, Artur ; Filgueira, Luis

In: Virology Journal, 2017, vol. 14, p. 8

Japanese encephalitis virus (JEV) is a neurotropic flavivirus causing mortality and morbidity in humans. Severe Japanese encephalitis cases display strong inflammatory responses in the central nervous system and an accumulation of viral particles in specific brain regions. Microglia cells are the unique brain-resident immune cell population with potent migratory functions and have been...

Université de Fribourg

Postprandial thermogenesis and respiratory quotient in response to galactose: comparison with glucose and fructose in healthy young adults

Charrière, Nathalie ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: Journal of Nutritional Science, 2016, vol. 5, p. -

Circumstantial evidence suggests that substitution of glucose or sucrose by the low- glycaemic index sugar galactose in the diet may lead to greater thermogenesis and/or fat oxidation. Using ventilated hood indirect calorimetry, we investigated, in twelve overnight-fasted adults, the resting energy expenditure (REE) and respiratory quotient (RQ) for 30 min before and 150 min after ingestion of...

Université de Fribourg

Fitting quotients of finitely presented abelian-by-nilpotent groups

Groves, John Richard James ; Strebel, Ralph

In: Journal of Group Theory, 2014, vol. 17, no. 1, p. 1-12

We show that every finitely generated nilpotent group of class 2 occurs as the quotient of a finitely presented abelian-by-nilpotent group by its largest nilpotent normal subgroup.