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Università della Svizzera italiana

Marine anticancer agents : an overview with a particular focus on their chemical classes

Barreca, Marilia ; Spanò, Virginia ; Montalbano, Alessandra ; Cueto, Mercedes ; Díaz Marrero, Ana R. ; Deniz, Irem ; Erdoğan, Ayşegül ; Lukić Bilela, Lada ; Moulin, Corentin ; Taffin-de-Givenchy, Elisabeth ; Spriano, Filippo ; Perale, Giuseppe ; Mehiri, Mohamed ; Rotter, Ana ; Thomas, Olivier P. ; Barraja, Paola ; Gaudêncio, Susana P. ; Bertoni, Francesco

In: Marine drugs, 2020, vol. 18, no. 12, p. 28

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from...

Université de Fribourg

Slow-targeted release of a ruthenium anticancer agent from vitamin B 12 functionalized marine diatom microalgae

Delasoie, Joachim ; Rossier, Jérémie ; Haeni, Laetitia ; Rothen-Rutishauser, Barbara ; Zobi, Fabio

In: Dalton Transactions, 2018, vol. 47, no. 48, p. 17221–17232

Herein we report the synthesis of a new biomaterial designed for targeted delivery of poorly water-soluble inorganic anticancer drugs, with a focus on colorectal cancer. Diatomaceous earth microparticles derived from marine microalgae were coated with vitamin B12 (cyanocobalamin) as a tumor targeting agent and loaded with the well- known anticancer agents cisplatin, 5-fluorouracil (5-FU), and...

Université de Fribourg

Shear stress-responsive polymersome nanoreactors inspired by the marine bioluminescence of dinoflagellates

Rifaie‐Graham, Omar ; Galensowske, Nikolas F. B. ; Dean, Charlie ; Pollard, Jonas ; Balog, Sandor ; Gouveia, Micael G. ; Chami, Mohamed ; Vian, Antoine ; Amstad, Esther ; Lattuada, Marco ; Bruns, Nico

In: Angewandte Chemie International Edition, 2020, vol. 60, no. 2, p. 904-909

Some marine plankton called dinoflagellates emit light in response to the movement of surrounding water, resulting in a phenomenon called milky seas or sea sparkle. The underlying concept, a shear-stress induced permeabilisation of biocatalytic reaction compartments, is transferred to polymer-based nanoreactors. Amphiphilic block copolymers that carry nucleobases in their hydrophobic block...

Université de Fribourg

A new species of the large-headed coastal marine turtle Solnhofia (Testudinata, Thalassochelydia) from the Late Jurassic of NW Switzerland

Anquetin, Jérémy ; Püntener, Christian

In: PeerJ, 2020, vol. 8, p. e9931

Background: The large-headed turtle Solnhofia parsonsi is known by a handful of specimens from the Late Jurassic of Germany and Switzerland (maybe also France). Solnhofia parsonsi is traditionally regarded as a “eurysternid” Thalassochelydia, a group of small to medium sized, mostly lagoonal or marginal turtles found almost exclusively in the Late Jurassic of Europe. More recently,...

Université de Fribourg

3D model related to the publication: A new species of the large-headed coastal marine turtle Solnhofia (Testudinata, Thalassochelydia) from the Late Jurassic of NW Switzerland

Anquetin, Jérémy ; Püntener, Christian

In: MorphoMuseuM, 2020, vol. 6, no. 4, p. e118

This contribution contains the 3D surface model of the holotype cranium of the Late Jurassic thalassochelydian turtle Solnhofia brachyrhyncha described and figured in the publication of Anquetin and Püntener (2020).

Université de Fribourg

Spatial and temporal analysis of meso- and microplastic pollution in the Ligurian and Tyrrhenian Seas

Caldwell, Jessica ; Muff, Livius F. ; Pham, Christopher K. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Lehner, Roman

In: Marine Pollution Bulletin, 2020, vol. 159, p. 111515

Areas like the Mediterranean coastlines, which have high population density, represent locations of high pollution risk for surrounding environments. Thus, this study aims to compare data on the abundance, size, and composition of buoyant plastic particles collected during two weeks in 2019 in the Ligurian and Tyrrhenian Seas with data from 2018. The results from 2019 show average meso- and ...

Université de Fribourg

Rapid and sensitive quantification of cell-associated multi-walled carbon nanotubes

Steinmetz, Lukas ; Bourquin, Joel ; Barosova, Hana ; Haeni, Laetitia ; Caldwell, Jessica ; Milosevic, Ana ; Geers, Christoph ; Bonmarin, Mathias ; Taladriz-Blanco, Patricia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nanoscale, 2020, vol. 12, no. 33, p. 17362–17372

Evaluating nanomaterial uptake and association by cells is relevant for in vitro studies related to safe-by-design approaches, nanomedicine or applications in photothermal therapy. However, standard analytical techniques are time-consuming, involve complex sample preparation or include labelling of the investigated sample system with e.g. fluorescent dyes. Here, we explore lock-in...

Université de Fribourg

A novel study on the inhibitory effect of marine macroalgal extracts on hyphal growth and biofilm formation of candidemia isolates

El-Zawawy, Nessma A. ; El-Shenody, Rania A. ; Ali, Sameh S. ; El-Shetehy, Mohamed

In: Scientific Reports, 2020, vol. 10, no. 1, p. 9339

Biofilm formation and hyphal growth are considered to be the most serious virulence factors of Candida species in blood causing candidemia infections, which are difficult to treat due to the spread of resistant Candida isolates to most antifungal drugs. Therefore, in this study, we investigated the effect of different types and concentrations of selected macroalgal extracts from Cladostephus...

Université de Fribourg

The last surviving Thalassochelydia — A new turtle cranium from the Early Cretaceous of the Purbeck Group (Dorset, UK)

Anquetin, Jérémy ; André, Charlotte

In: PaleorXiv, 2020, p. 7pa5c

Background. The mostly Berriasian (Early Cretaceous) Purbeck Group of southern England has produced a rich turtle fauna dominated by the freshwater paracryptodires Pleurosternon bullockii and Dorsetochelys typocardium. Each of these species is known by numerous relatively complete shells and by a single cranium. The two other turtles found in the Purbeck Group (Hylaeochelys belli, a species of...

Université de Fribourg

Foraminiferal-based biotic indices to assess the ecological quality status of the Gulf of Gabes (Tunisia): Present limitations and future perspectives

Kateb, Akram El ; Stalder, Claudio ; Martínez-Colón, Michael ; Mateu-Vicens, Guillem ; Francescangeli, Fabio ; Coletti, Giovanni ; Stainbank, Stephanie ; Spezzaferri, Silvia

In: Ecological Indicators, 2020, vol. 111, p. 105962

Biotic indices are tools to assess the ecological status of marine systems, and can be based on different metrics (such as ecological groups, specific diversity). The present study applies five biotic indices based on living (stained) benthic foraminiferal assemblages to assess ecological conditions in a wide area of the Mediterranean Sea in the heavily polluted Gulf of Gabes and along the...