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Università della Svizzera italiana

Targeting the DNA damage response for patients with lymphoma : preclinical and clinical evidences

Carrassa, Laura ; Colombo, Ilaria ; Damia, Giovanna ; Bertoni, Francesco

In: Cancer treatment reviews, 2020, vol. 90, p. 11

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...

Université de Fribourg

Multiscale community estimation based on temporary local balancing strategy

Zhou, Qiang ; Cai, Shi-Min ; Zhang, Yi-Cheng

In: International Journal of Modern Physics C, 2020, vol. 31, no. 04, p. 2050056

Community division in complex networks has become one of the hot topics in the field of network science. Most of the methods developed based on network topology ignore the dynamic characteristics underlying the structure. By exploring the diffusion process in the network based on random walk, this paper sums up the general rule with temporal characteristics as a temporary local balancing...

Université de Fribourg

Phase separation in the vicinity of Fermi surface hot spots

Jaouen, Thomas ; Hildebrand, Baptiste ; Mottas, Marie-Laure ; Giovannantonio, M. Di ; Ruffieux, Pascal ; Rumo, Maxime ; Nicholson, Christopher W. ; Razzoli, E. ; Barreteau, C. ; Ubaldini, A. ; Giannini, E. ; Vanini, Fabiano ; Beck, Hans ; Monney, Claude ; Aebi, Philipp

In: Physical Review B, 2019, vol. 100, no. 7, p. 075152

Spatially inhomogeneous electronic states are expected to be key ingredients for the emergence of superconducting phases in quantum materials hosting charge-density waves (CDWs). Prototypical materials are transitionmetal dichalcogenides (TMDCs) and among them, 1T-TiSe2 exhibiting intertwined CDW and superconducting states under Cu intercalation, pressure, or electrical gating. Although it...

Université de Fribourg

DNA‐mediated self‐assembly of plasmonic antennas with a single quantum dot in the hot spot

Nicoli, Francesca ; Zhang, Tao ; Hübner, Kristina ; Jin, Boyuan ; Selbach, Florian ; Acuna, Guillermo P. ; Argyropoulos, Christos ; Liedl, Tim ; Pilo-Pais, and Mauricio

In: Small, 2019, vol. 15, no. 26, p. 1804418

DNA self‐assembly is a powerful tool to arrange optically active components with high accuracy in a large parallel manner. A facile approach to assemble plasmonic antennas consisting of two metallic nanoparticles (40 nm) with a single colloidal quantum dot positioned at the hot spot is presented here. The design approach is based on DNA complementarity, stoichiometry, and steric hindrance...

Université de Fribourg

A gardener’s influence on urban soil quality

Tresch, Simon ; Moretti, Marco ; Le Bayon, Renée-Claire ; Mäder, Paul ; Zanetta, Andrea ; Frey, David ; Fliessbach, Andreas

In: Frontiers in Environmental Science, 2018, vol. 6, p. -

Gardens are hot spots for urban biodiversity and provide habitats for many plant and animal species, both above- and below-ground. Furthermore, gardens provide a wide range of ecosystem services, including carbon (C) storage and nutrient cycling. Although the soil is the foundation of sustainable gardens providing those ecosystem services, very little is known about the consequences of garden...

Università della Svizzera italiana

Exposing concurrency failures : a comprehensive survey of the state of the art and a novel approach to reproduce field failures

Bianchi, Francesco Adalberto ; Pezzè, Mauro (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO015.

With the rapid advance of multi-core and distributed architectures, concurrent systems are becoming more and more popular. Concurrent systems are extremely hard to develop and validate, as their overall behavior depends on the non-deterministic interleaving of the execution flows that comprise the system. Wrong and unexpected interleavings may lead to concurrency faults that are extremely...

Université de Fribourg

Early and late cardiovascular and metabolic responses to mixed wine: effect of drink temperature

Sarafian, Delphine ; Maufrais, Claire ; Montani, Jean-Pierre

In: Frontiers in Physiology, 2018, vol. 9, p. -

Aim: Red wine is usually ingested as an unmixed drink. However, mixtures of wine with juices and/or sucrose (mixed wine) are becoming more and more popular and could be ingested at either cold or hot temperature. Although the temperature effects on the cardiovascular system have been described for water and tea, with greater energy expenditure (EE) and lower cardiac workload with a colder...

Université de Fribourg

Brownian dynamics of colloidal microspheres with tunable elastic properties from soft to hard

Yoon, Jiwon ; Cardinaux, Frédéric ; Lapointe, Clayton ; Zhang, Chi ; Mason, Thomas G. ; Ahn, Kyung Hyun ; Scheffold, Frank

In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018, vol. 546, p. 360–365

We study the Brownian thermal motion of a colloidal model system made by emulsifying hot liquid α-eicosene wax into an aqueous surfactant solution of sodium dodecyl sulfate (SDS). When this waxy oil-in-water emulsion is cooled below α- eicosene's melting point of Tc ≃ 25 °C, the microscale emulsion droplets solidify, effectively yielding a dispersed particulate system. So, the...

Université de Fribourg

Cardiovascular and metabolic responses to the ingestion of caffeinated herbal tea: drink it hot or cold?

Maufrais, Claire ; Sarafian, Delphine ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Frontiers in Physiology, 2018, vol. 9, p. -

Tea is usually consumed at two temperatures (as hot tea or as iced tea). However, the importance of drink temperature on the cardiovascular system and on metabolism has not been thoroughly investigated. The purpose of this study was to compare the cardiovascular, metabolic and cutaneous responses to the ingestion of caffeinated herbal tea (Yerba Mate) at cold or hot temperature in healthy...