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Université de Fribourg

Ecological Monitoring and Management App (EMMA) for Older Adults With Chronic Pain: Protocol for a Design and Feasibility Study

Ledermann, Katharina ; Abou Khaled, Omar ; Caon, Maurizio ; Berger, Thomas ; Chabwine, Joelle ; Martin-Soelch, Chantal

In: JMIR Research Protocols

Background: Chronic pain is a complex problem for many older adults that affects both physical functioning and psychological well-being. Mobile health (mHealth) technologies have shown promise in supporting older persons in managing chronic conditions. Cognitive behavior therapy (CBT) is recommended for older people with chronic pain. However, online treatment programs for chronic pain are...

Università della Svizzera italiana

Antibody-guided vaccine design : identification of protective epitopes

Lanzavecchia, Antonio ; Frühwirth, Alexander ; Perez, Laurent ; Corti, Davide

In: Current opinion in immunology, 2016, vol. 41, no. August, p. 62-67

In the last decade, progress in the analysis of the human immune response and in the isolation of human monoclonal antibodies have provided an innovative approach to the identification of protective antigens which are the basis for the design of vaccines capable of eliciting effective B-cell immunity. In this review we illustrate, with relevant examples, the power of this approach that can...

Université de Fribourg

Enigmatic dinosaur precursors bridge the gap to the origin of Pterosauria

Ezcurra, Martín D. ; Nesbitt, Sterling J. ; Bronzati, Mario ; Vecchia, Fabio Marco Dalla ; Agnolin, Federico L. ; Benson, Roger B. J. ; Egli, Federico Brissón ; Cabreira, Sergio F. ; Evers, Serjoscha W. ; Gentil, Adriel R. ; Irmis, Randall B. ; Martinelli, Agustín G. ; Novas, Fernando E. ; Silva, Lúcio Roberto da ; Smith, Nathan D. ; Stocker, Michelle R. ; Turner, Alan H. ; Langer, Max C.

In: Nature, 2020, vol. 588, no. 2020-7838, p. 445–449

Pterosaurs were the first vertebrates to evolve powered flight1 and comprised one of the main evolutionary radiations in terrestrial ecosystems of the Mesozoic era (approximately 252–66 million years ago), but their origin has remained an unresolved enigma in palaeontology since the nineteenth century2,3,4. These flying reptiles have been hypothesized to be the close relatives of a wide...

Università della Svizzera italiana

Simplifying offloading applications to the network

Bressana, Pietro Giuseppe ; Soulé, Robert (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO011.

Recent advancements in the networking field have made the data plane fully programmable, thanks to the introduction of both programmable network architectures and network programming languages. P4, the most prominent network programming language, provides software abstractions to the components of PISA, a programmable network architecture that is able to process huge amounts of network ...

Université de Fribourg

On trends and patterns in macroevolution: Williston’s law and the branchiostegal series of extant and extinct osteichthyans

Ascarrunz, Eduardo ; Sánchez-Villagra, Marcelo R. ; Betancur, Ricardo ; Laurin, Michel

In: BMC Evolutionary Biology, 2019, vol. 19, no. 1, p. 117

The branchiostegal series consists of an alignment of bony elements in the posterior portion of the skull of osteichthyan vertebrates. We trace the evolution of the number of elements in a comprehensive survey that includes 440 extant and 66 extinct species. Using a newly updated actinopterygian tree in combination with phylogenetic comparative analyses, we test whether osteichthyan...

Université de Fribourg

Evaluation of a lifestyle change programme for the treatment of obesity in general practice

Munsch, Simone ; Biedert, Esther ; Keller, Ulrich

In: Swiss Medical Weekly, 2003, vol. 133, p. 148-154

In order to evaluate the effectiveness of a cognitive behavioural group therapy programme for the treatment of obesity in clinical practice, 122 patients from 14 general practices (n = 70) were randomised into either a treatment or a control arm with a ratio of 3 to 2. The group treatment programme was also assessed in a clinical centre (n = 52; University Hospital Basel). Before therapy, a...