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Università della Svizzera italiana

A LAIR-1 insertion creates broadly reactive antibodies against malaria variant antigens

Tan, Joshua ; Pieper, Kathrin ; Piccoli, Luca ; Abdi, Abdirahman ; Tully, Claire Maria ; Foglierini Perez, Mathilde ; Geiger, Roger ; Jarrossay, David ; Maina Ndungu, Francis ; Wambua, Juliana ; Bejon, Philip ; Silacci Fregni, Chiara : Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland ; Fernandez-Rodriguez, Blanca ; Barbieri, Sonia ; Bianchi, Siro ; Marsh, Kevin ; Thathy, Vandana ; Corti, Davide ; Sallusto, Federica ; Bull, Peter ; Lanzavecchia, Antonio

In: Nature, 2016, vol. 529, p. 25 p

Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies1,2,3,4. Although broadly reactive antibodies against these antigens could be useful as therapeutics and in vaccine design, their...

Université de Fribourg

Isolation of cellulose nanofibers from Oryza sativa residues via tempo mediated oxidation

Madivoli, Edwin S. ; Kareru, Patrick G. ; Gachanja, Anthony N. ; Mugo, Samuel M. ; Sujee, David M. ; Fromm, Katharina M.

In: Journal of Natural Fibers, 2020, p. 1–13

Cellulose nanocrystals (CNCs) or cellulose nanofibers (CNFs) with different morphologies, chemical, mechanical and physical properties can be obtained when microcrystalline cellulose is subjected to enzymatic, chemical or mechanical treatment. With the aim of utilizing cellulose nanofibrils (CNFs) from Oryza sativa, we isolated microcrystalline cellulose using the Kraft process, followed by...

Université de Fribourg

Disentangling the effects of external perturbations on coexistence and priority effects

Song, Chuliang ; Rohr, Rudolf P. ; Vasseur, David ; Saavedra, Serguei

In: Journal of Ecology, 2020, p. 1365-2745.13349

A major challenge in ecological research is to identify the tolerance of ecological communities to external perturbations. Modern coexistence theory (MCT) has been widely adopted as a framework to investigate the tolerance to perturbations in relative reductions of per capita growth rates, often using metrics that explicitly eliminate the independent role of intrinsic growth rates. More...

Université de Fribourg

Comparative analysis of the shape and size of the middle ear cavity of turtles reveals no correlation with habitat ecology

Foth, Christian ; Evers, Serjoscha W. ; Joyce, Walter G. ; Volpato, Virginie S. ; Benson, Roger B. J.

In: Journal of Anatomy, 2019, no. 0, p. -

The middle ear of turtles differs from other reptiles in being separated into two distinct compartments. Several ideas have been proposed as to why the middle ear is compartmentalized in turtles, most suggesting a relationship with underwater hearing. Extant turtle species span fully marine to strictly terrestrial habitats, and ecomorphological hypotheses of turtle hearing predict that this...

Université de Fribourg

Ecological constraints coupled with deep-time habitat dynamics predict the latitudinal diversity gradient in reef fishes

Gaboriau, Théo ; Albouy, Camille ; Descombes, Patrice ; Mouillot, David ; Pellissier, Loïc ; Leprieur, Fabien

In: Proceedings of the Royal Society B: Biological Sciences, 2019, vol. 286, no. 1911, p. 20191506

We develop a spatially explicit model of diversification based on palaeohabitat to explore the predictions of four major hypotheses potentially explaining the latitudinal diversity gradient (LDG), namely, the ‘time-area’, ‘tropical niche conservatism’, ‘ecological limits’ and ‘evolutionary speed’ hypotheses. We compare simulation outputs to observed diversity gradients in the...

Université de Fribourg

Middle-income groups in Kenya : Conflicting realities between upward mobility and uncertainty

Neubert, Dieter

In:, 2019, vol. 1, no. 4, p. Article: 1.4

For more than a decade scholars mostly from economy and development studies have described the rise of a newly emerging ‘middle class’ in the Global South including Africa. This has led to a ‘middle class narrative’ with the ‘middle class’ as the backbone of economic and democratic development. Especially with regard to the stability of the position of the people in the ‘middle’,...

Université de Fribourg

Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro

Liljander, Anne ; Sacchini, Flavio ; Stoffel, Michael H. ; Schieck, Elise ; Stokar‑Regenscheit, Nadine ; Labroussaa, Fabien ; Heller, Martin ; Salt, Jeremy ; Frey, Joachim ; Falquet, Laurent ; Goovaerts, Danny ; Jores, Joerg

In: Veterinary Research, 2019, vol. 50, no. 1, p. 10

Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae is a severe disease widespread in Africa and Asia. Limited knowledge is available on the pathogenesis of this organism, mainly due to the lack of a robust in vivo challenge model and the means to do site-directed mutagenesis. This work describes the establishment of a novel caprine challenge...

Université de Fribourg

A guideline to study the feasibility domain of multi-trophic and changing ecological communities

Song, Chuliang ; Rohr, Rudolf P. ; Saavedra, Serguei

In: Journal of Theoretical Biology, 2018, vol. 450, p. 30–36

The feasibility domain of an ecological community can be described by the set of environmental abiotic and biotic conditions under which all co-occurring and interacting species in a given site and time can have positive abundances. Mathematically, the feasibility domain corresponds to the parameter space compatible with positive (feasible) solutions at equilibrium for all the state variables...