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Université de Fribourg

Late Jurassic theropod dinosaur bones from the Langenberg Quarry (Lower Saxony, Germany) provide evidence for several theropod lineages in the central European archipelago

Evers, Serjoscha W. ; Wings, Oliver

In: PeerJ, 2020, vol. 8, p. e8437

Marine limestones and marls in the Langenberg Quarry provide unique insights into a Late Jurassic island ecosystem in central Europe. The beds yield a varied assemblage of terrestrial vertebrates including extremely rare bones of theropod from theropod dinosaurs, which we describe here for the first time. All of the theropod bones belong to relatively small individuals but represent a wide...

Università della Svizzera italiana

New insights in chemokine signaling

Legler, Daniel F. ; Thelen, Marcus

In: F1000Research, 2018, vol. 7, p. 95

Chemokine signaling is essential for coordinated cell migration in health and disease to specifically govern cell positioning in space and time. Typically, chemokines signal through heptahelical, G protein-coupled receptors to orchestrate cell migration. Notably, chemokine receptors are highly dynamic structures and signaling efficiency largely depends on the discrete contact with the ligand....

Université de Fribourg

The Evolution of Aging

Fabian, Daniel ; Flatt, Thomas

In: Nature Education Knowledge, 2011, vol. 3, no. 3, p. 1-10

Université de Fribourg

A new testudinoid turtle from the middle to late Eocene of Vietnam

Garbin, Rafaella C. ; Böhme, Madelaine ; Joyce, Walter G.

In: PeerJ, 2019, vol. 7, p. e6280

Testudinoidea is a major clade of turtles that has colonized different ecological environments across the globe throughout the Tertiary. Aquatic testudinoids have a particularly rich fossil record in the Tertiary of the northern hemisphere, but little is known about the evolutionary history of the group, as the phylogenetic relationships of most fossils have not been established with...

Université de Fribourg

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Formento, Emanuele ; Minassian, Karen ; Wagner, Fabien ; Mignardot, Jean Baptiste ; Le Goff-Mignardot, Camille G. ; Rowald, Andreas ; Bloch, Jocelyne ; Micera, Silvestro ; Capogrosso, Marco ; Courtine, Gregoire

In: Nature Neuroscience, 2018, vol. 21, no. 12, p. 1728–1741

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and proprioceptive information in humans. Computational simulations and preclinical and clinical experiments reveal that EES blocks a significant amount of...

Université de Fribourg

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Capogrosso, Marco ; Wagner, Fabien B. ; Gandar, Jerome ; Moraud, Eduardo Martin ; Wenger, Nikolaus ; Milekovic, Tomislav ; Shkorbatova, Polina ; Pavlova, Natalia ; Musienko, Pavel ; Bezard, Erwan ; Bloch, Jocelyne ; Courtine, Grégoire

In: Nature Protocols, 2018, vol. 13, no. 9, p. 2031–2061

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipment and surgical procedures that can be used to acquire chronic electromyographic (EMG) recordings from leg muscles and to implant targeted...

Université de Fribourg

Eliminating the VGlut2-dependent glutamatergic transmission of parvalbumin-expressing neurons leads to deficits in locomotion and vocalization, decreased pain sensitivity, and increased dominance

Roccaro-Waldmeyer, Diana M. ; Girard, Franck ; Milani, Daniele ; Vannoni, Elisabetta ; Prétôt, Laurent ; Wolfer, David P. ; Celio, Marco R.

In: Frontiers in Behavioral Neuroscience, 2018, vol. 12, p. -

The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. However in addition, PV is expressed by excitatory, glutamatergic neurons in various areas of the brain and spinal cord. Depending on the location of these neurons, loading of their synaptic vesicles with glutamate is mediated by either of three vesicular...