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Université de Fribourg

The rise of angiosperms pushed conifers to decline during global cooling

Condamine, Fabien L. ; Silvestro, Daniele ; Koppelhus, Eva B. ; Antonelli, Alexandre

In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 46, p. 28867–28875

Competition among species and entire clades can impact species diversification and extinction, which can shape macroevolutionary patterns. The fossil record shows successive biotic turnovers such that a dominant group is replaced by another. One striking example involves the decline of gymnosperms and the rapid diversification and ecological dominance of angiosperms in the Cretaceous. It is...

Università della Svizzera italiana

A novel interaction between the TLR7 and a colchicine derivative revealed through a computational and experimental study

Gentile, Francesco ; Deriu, Marco A. ; Barakat, Khaled ; Danani, Andrea ; Tuszynski, Jack

In: Pharmaceuticals, 2018, vol. 11, no. 1, p. 22

The Toll-Like Receptor 7 (TLR7) is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837) and resiquimod (R-848). Recently, an interaction between R-837 and the colchicine binding site of tubulin was reported. To investigate the possibility of an interaction between...

Consortium of Swiss Academic Libraries

Parks Canada Issues New Policy

Eidsvik, Harold K.

In: Environmental Conservation, 1979, vol. 6, no. 4, p. 292-292