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Università della Svizzera italiana

Autoimmmune hepatitis

Terziroli Beretta-Piccoli, Benedetta ; Mieli Vergani, Giorgina ; Vergani, Diego

In: Cellular & molecular immunology, 2021, p. 19

Autoimmune hepatitis (AIH) is a T-cell mediated, inflammatory liver disease affecting all ages and characterized by female preponderance, elevated serum transaminase and immunoglobulin G levels, positive circulating autoantibodies, and presence of interface hepatitis at liver histology. AIH type 1, affecting both adults and children, is defined by positive anti- nuclear and/or antismooth muscle...

Università della Svizzera italiana

Autoimmune hepatitis : serum autoantibodies in clinical practice

Terziroli Beretta-Piccoli, Benedetta ; Mieli Vergani, Giorgina ; Vergani, Diego

In: Clinical reviews in allergy & immunology, 2021, p. 14

Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to dedicated guidelines issued by the International Autoimmune Hepatitis Group. They also allow the distinction between type 1 AIH, characterized by positive anti-nuclear and/or anti-smooth muscle antibody, and type 2 AIH, characterized by positive...

Università della Svizzera italiana

Recommendations on screen time, sleep and physical activity : associations with academic achievement in Swiss adolescents

Marciano, Laura ; Camerini, Anne-Linda

In: Public health, 2021, vol. 198, p. 211-217

Objectives: This study aimed to investigate how meeting international recommendations for screen time (<2 h/day), moderate-to-vigorous physical activity (MVPA; at least 60 min/day) and sleep (8e10 h/night), as well as media multitasking (MMI) as a form of screen time, impact academic achievement in early adolescence. Study design: A prospective design was used, where self-report measures...

Università della Svizzera italiana

Inflation bald als Folgeeffekt der COVID-19-Pandemie? = Inflation soon a consequence of the COVID-19 pandemic?

Beretta, Edoardo

In: List Forum für Wirtschafts- und Finanzpolitik, 2021, vol. 46, no. 3, p. 359-377

Although COVID-19 pandemic has so far been assumed to have recessivedeflationary consequences due to the dramatic deterioration of economic forecasts worldwide, inflation risks cannot be excluded. What effects might result from the combination of billion-high liquidity injections and high decline in production levels as well as strict (and costly) security and protection requirements? And why...

Università della Svizzera italiana

Pre-existing cardiovascular conditions as clinical predictors of myocarditis reporting with immune checkpoint inhibitors : a VigiBase study

Noseda, Roberta ; Ruinelli, Lorenzo ; van der Gaag, Linda C. ; Ceschi, Alessandro

In: Cancers, 2020, vol. 12, no. 11, p. 15

Up to 50% of myocarditis events developed in cancer patients upon treatment with immune checkpoint inhibitors (ICIs) are fatal. Therefore, identification of clinical risk factors predicting myocarditis onset during treatment with ICIs is important for the purpose of cardiac surveillance of high-risk patients. The aim of this retrospective matched case-control study was to assess whether...

Università della Svizzera italiana

Dietary chloride deficiency syndrome : pathophysiology, history, and systematic literature review

Signorelli, Giulia C. ; Bianchetti, Mario G. ; Jermini, Luca M. M. ; Agostoni, Carlo ; Milani, Gregorio P. ; Simonetti, Giacomo D. ; Lava, Sebastiano A. G.

In: Nutrients, 2020, vol. 12, no. 11, p. 10 p

Metabolic alkalosis may develop as a consequence of urinary chloride (and sodium) wasting, excessive loss of salt in the sweat, or intestinal chloride wasting, among other causes. There is also a likely underrecognized association between poor salt intake and the mentioned electrolyte and acid–base abnormality. In patients with excessive loss of salt in the sweat or poor salt intake, the...

Università della Svizzera italiana

Detecting Alzheimer’s disease (AD) : from the asymptomatic stages of healthy adults with AD genetic disposition to late stages of severe neurocognitive impairment

Ibnidris, Aliaa ; Albanese, Emiliano (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2021 ; 2021BIOMED001.

Background: Dementia is a syndrome characterized by progressive cognitive impairment, psychological and behavioural symptoms, and functional deficits. It is one of the leading causes of disability worldwide; its impact and the associated costs are enormous. Consequently, dementia is a global public health priority, and so is Alzheimer’s disease (AD), the most common cause of dementia in late...

Università della Svizzera italiana

The ultrasound risk stratification systems for thyroid nodule have been evaluated against papillary carcinoma : a meta-analysis

Trimboli, Pierpaolo ; Castellana, Marco ; Piccardo, Arnoldo ; Romanelli, Francesco ; Grani, Giorgio ; Giovanella, Luca ; Durante, Cosimo

In: Reviews in endocrine and metabolic disorders, 2020, p. 8 p

Thyroid imaging reporting and data systems (TIRADS) are used to stratify the malignancy risk of thyroid nodule by ultrasound (US) examination. We conducted a meta-analysis to evaluate the pooled cancer prevalence and the relative prevalence of papillary, medullary, follicular thyroid cancer (PTC, MTC, and FTC) and other malignancies among nodules included in studies evaluating their...

Haute école de gestion de Genève

Spain and Switzerland: observation of the management of the Covid-19 crisis and its economic impact

Poch, Julien ; Pasche, Cyril (Dir.)

Mémoire de bachelor : Haute école de gestion de Genève, 2021 ; TDEE 455.

Under normal conditions, economies go through boom-and-bust cycles. Covid-19 highlighted the problem of uncertainty in the economy that authors such as Frank Knight have proposed, particularly the unpredictable nature of economic systems. It is in this aspect that the analysis of the phenomenon is of particular interest, with the aim of understanding the repercussions that the response, in the...