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Université de Fribourg

Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii

Cebrero-Cangueiro, T. ; Nordmann, Patrice ; Carretero-Ledesma, M. ; Pachón, J. ; Pachón-Ibáñez, M. E.

In: Journal of Antimicrobial Chemotherapy, 2020, p. dkaa487

Objectives: To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus meropenem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58.Methods: An experimental model of peritonitis using C57BL/6J female mice was developed and the minimum lethal doses were calculated for infections due to OXA-23 or OXA-58 producers of A. ...

Université de Fribourg

Implementation and evaluation of methods for the optimal detection of carbapenem-resistant and colistin-resistant Pseudomonas aeruginosa and Acinetobacter baumannii from stools

Fournier, Claudine ; Poirel, Laurent ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2020, vol. 98, no. 2, p. 115121

Carbapenem-resistant Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA), as well as polymyxin-resistant A. baumannii (PMR-AB) and P. aeruginosa (PMR-PA), were used to test different enrichment strategies from spiked stools. Three procedures were compared, namely, direct inoculation on selective plates and plating after a 24-h enrichment step in tryptic soy broth with or without ...

Université de Fribourg

Adapting spherical-harmonics-based geometric morphometrics (SPHARM) for 3D images containing large cavity openings using ambient occlusion: a study with hermit crab claw shape variability

Ege, Yannic C. ; Foth, Christian ; Baum, Daniel ; Wirkner, Christian S. ; Richter, Stefan

In: Zoomorphology, 2020, p. -

One of the advantages of mesh-based geometric morphometrics (GM) over landmark-based approaches, is that it affords the possibility of the precise examination of highly irregular shapes and complex topographic surfaces. In the case of spherical-harmonic-based GM, the main prerequisite is a completely closed mesh surface, which is often lacking, particularly when dealing with natural objects....

Université de Fribourg

Evaluation of resazurin-based rapid test to detect colistin resistance in Acinetobacter baumannii isolates

Germ, Julija ; Poirel, Laurent ; Cerar Kisek, Tjasa ; Cvitkovic Spik, Vesna ; Katja Seme ; Mueller Premru, Manica ; Lejko Zupanc, Tatjana ; Nordmann, Patrice ; Pirs, Mateja

In: European Journal of Clinical Microbiology & Infectious Diseases, 2019, vol. 38, no. 11, p. 2159–2162

Acinetobacter baumannii primarily causes colonization, yet it can be an opportunistic pathogen associated with hospital-acquired infections. Many countries report rapid spread of carbapenem-resistant Acinetobacter baumannii (CRAb) which limits treatment options, with colistin frequently being the last line treatment option. The aim of our study was to evaluate a recently developed rapid...

Université de Fribourg

No evidence that frontal optical flow affects perceived locomotor speed and locomotor biomechanics when running on a treadmill

Caramenti, Martina ; Lafortuna, Claudio L. ; Mugellini, Elena ; Khaled, Omar Abou ; Bresciani, Jean-Pierre ; Dubois, Amandine

In: Applied Sciences, 2019, vol. 9, no. 21, p. 4589

We investigated how the presentation and the manipulation of an optical flow while running on a treadmill affect perceived locomotor speed (Experiment 1) and gait parameters (Experiment 2). In Experiment 1, 12 healthy participants were instructed to run at an imposed speed and to focus on their sensorimotor sensations to be able to reproduce this running speed later. After a pause, they had...

Université de Fribourg

Epibenthos dynamics and environmental fluctuations in two contrasting polar carbonate factories (Mosselbukta and Bjørnøy-banken, svalbard)

Wisshak, Max ; Neumann, Hermann ; Rüggeberg, Andres ; Büscher, Janina V. ; Linke, Peter ; Raddatz, Jacek

In: Frontiers in Marine Science, 2019, vol. 6, p. -

The Arctic Svalbard Archipelago hosts the world’s northernmost cold-water ‘carbonate factories’ thriving here despite of presumably unfavourable environmental conditions and extreme seasonality. Two contrasting sites of intense biogenic carbonate production, the rhodolith beds in Mosselbukta in the north of the archipelago and the barnacle-mollusc dominated carbonate sediments...

Université de Fribourg

Regular physical activity modulates perceived visual speed when running in treadmill-mediated virtual environments

Caramenti, Martina ; Lafortuna, Claudio L. ; Mugellini, Elena ; Khaled, Omar Abou ; Bresciani, Jean-Pierre ; Dubois, Amandine

In: PLOS ONE, 2019, vol. 14, no. 6, p. e0219017

In virtual reality, visual speed is usually underestimated relative to locomotor speed. Here we investigated how physical activity and fitness affect perceived visual speed when running in a treadmill-mediated virtual environment. Thirty healthy participants (ten sedentary individuals, ten team sport players and ten expert runners) ran on a treadmill at two different speeds (8, 12km/h) in...

Università della Svizzera italiana

On the Lebesgue constant of barycentric rational Hermite interpolants at equidistant nodes

Cirillo, Emiliano ; Hormann, Kai

In: Journal of computational and applied mathematics, 2019, vol. 349, p. 292-301

Barycentric rational Floater–Hormann interpolants compare favourably to classical polynomial interpolants in the case of equidistant nodes, because the Lebesgue constant associated with these interpolants grows logarithmically in this setting, in contrast to the exponential growth experienced by polynomials. In the Hermite setting, in which also the first derivatives of the interpolant are...

Università della Svizzera italiana

Advances in barycentric rational interpolation of a function and its derivatives

Cirillo, Emiliano ; Hormann, Kai (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO007.

Linear barycentric rational interpolants are a particular kind of rational interpolants, defined by weights that are independent of the function f. Such interpolants have recently proved to be a viable alternative to more classical interpolation methods, such as global polynomial interpolants and splines, especially in the equispaced setting. Other kinds of interpolants might indeed suffer...