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Université de Fribourg

Phosphorylation and circadian molecular timing

Brenna, Andrea ; Albrecht, Urs

In: Frontiers in Physiology, 2020, vol. 11, p. -

Endogenous circadian rhythms are biological processes generated by an internal body clock. They are self-sustaining, and they govern biochemical and physiological processes. However, circadian rhythms are influenced by many external stimuli to reprogram the phase in response to environmental change. Through their adaptability to environmental changes, they synchronize physiological responses...

Université de Fribourg

Slow-targeted release of a ruthenium anticancer agent from vitamin B 12 functionalized marine diatom microalgae

Delasoie, Joachim ; Rossier, Jérémie ; Haeni, Laetitia ; Rothen-Rutishauser, Barbara ; Zobi, Fabio

In: Dalton Transactions, 2018, vol. 47, no. 48, p. 17221–17232

Herein we report the synthesis of a new biomaterial designed for targeted delivery of poorly water-soluble inorganic anticancer drugs, with a focus on colorectal cancer. Diatomaceous earth microparticles derived from marine microalgae were coated with vitamin B12 (cyanocobalamin) as a tumor targeting agent and loaded with the well- known anticancer agents cisplatin, 5-fluorouracil (5-FU), and...

Université de Fribourg

Integrated bio- and cyclostratigraphy of Middle Triassic (Anisian) ramp deposits, NW Bulgaria

Ajdanlijsky, George ; Strasser, André ; Götz, Annette E.

In: Geologica Carpathica, 2019, vol. 70, no. 4, p. 325–354

A cyclostratigraphic interpretation of peritidal to shallow-marine ramp deposits of the early Middle Triassic (Anisian) Opletnya Member exposed in outcrops along the Iskar River gorge, NW Bulgaria, is presented. Based on facies trends and bounding surfaces, depositional sequences of several orders can be identified. New biostratigraphic data provide a time frame of the studied succession with...

Université de Fribourg

Cyclostratigraphy of shallow-marine carbonates – limitations and opportunities

Strasser, André

In: Stratigraphy & Timescales, 2018, vol. 3, p. 151–187

The sedimentary record of ancient shallow-marine carbonate platforms commonly displays a stacking of different facies, which reflects repetitive changes of depositional environments through time. These changes can be induced by external factors such as cyclical changes in climate and/or sea level, but also by internal factors such as lateral migration of sediment bodies and/or changes in the...

Université de Fribourg

What do we really know about early diagenesis of non-marine carbonates?

Boever, Eva De ; Brasier, Alexander T. ; Foubert, Anneleen ; Kele, Sándor

In: Sedimentary Geology, 2017, vol. 361, p. 25–51

Non-marine carbonate rocks including cave, spring, stream, calcrete and lacustrine- palustrine sediments, are susceptible to early diagenetic processes. These can profoundly alter the carbonate fabric and affect paleoclimatic proxies. This review integrates recent insights into diagenesis of non-marine carbonates and in particular the variety of early diagenetic processes, and presents a...

Consortium of Swiss Academic Libraries

Is Gaia endothermic?

Hsü, K. J.

In: Geological Magazine, 1992, vol. 129, no. 2, p. 129-141

Université de Fribourg

Experimental evidence of an eco-evolutionary feedback during adaptive divergence

Matthews, Blake ; Aebischer, Thierry ; Sullam, Karen E. ; Lundsgaard-Hansen, Bänz ; Seehausen, Ole

In: Current Biology, 2016, vol. 26, no. 4, p. 483–489

Differences in how organisms modify their environment can evolve rapidly and might influence adaptive population divergence [1 and 2]. In a common garden experiment in aquatic mesocosms, we found that adult stickleback from a recently diverged pair of lake and stream populations had contrasting effects on ecosystem metrics. These modifications were caused by both genetic and plastic...