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Università della Svizzera italiana

Intestinal microbiota drives cholestasis-induced specific hepatic gene expression patterns

Juanola, Oriol ; Hassan, Mohsin ; Kumar, Pavitra ; Yilmaz, Bahtiyar ; Keller, Irene ; Simillion, Cédric ; Engelmann, Cornelius ; Tacke, Frank ; Dufour, Jean-François ; De Gottardi, Andrea ; Moghadamrad, Sheida

In: Gut microbes, 2021, vol. 13, no. 1, p. 20

Intestinal microbiota regulates multiple host metabolic and immunological processes. Consequently, any difference in its qualitative and quantitative composition is susceptible to exert significant effects, in particular along the gut-liver axis. Indeed, recent findings suggest that such changes modulate the severity and the evolution of a wide spectrum of hepatobiliary disorders. However, the...

Université de Fribourg

Identification of a species-specific aminotransferase in Pediococcus acidilactici capable of forming α-aminobutyrate

Wenger, Alexander ; Schmidt, Remo S. ; Portmann, Reto ; Roetschi, Alexandra ; Eugster, Elisabeth ; Weisskopf, Laure ; Irmler, Stefan

In: AMB Express, 2020, vol. 10, no. 1, p. 100

During cheese ripening, the bacterial strain Pediococcus acidilactici FAM18098 produces the non-proteinogenic amino acid, α-aminobutyrate (AABA). The metabolic processes that lead to the biosynthesis of this compound are unknown. In this study, 10 P. acidilactici, including FAM18098 and nine Pediococcus pentosaceus strains, were screened for their ability to produce AABA. All P. acidilactici...

Université de Fribourg

Short-term cardiovascular responses to ingestion of mineral water in healthy non-obese adults: Impact of mineral components

Monnard, Cathriona Rosemary ; Montani, Jean-Pierre ; Grasser, Erik Konrad

In: Journal of Functional Foods, 2020, vol. 71, p. 104017

Background: The role of mineral components in the hemodynamic response to water drinking is still elusive.Methods: We conducted a randomized crossover study in 16 non-obese, healthy subjects (8 women) to investigate cardiovascular responses to water drinks differing in the mineral content. Continuous measurements included beat- to-beat blood pressure, electrocardiography derived RR-intervals,...

Università della Svizzera italiana

Isonitrile-based multicomponent synthesis of β-amino boronic acids as β-lactamase inhibitors

Bassini, Emanuele ; Gazzotti, Stefano ; Sannio, Filomena ; Lo Presti, Leonardo ; Sgrignani, Jacopo ; Docquier, Jean-Denis ; Grazioso, Giovanni ; Silvani, Alessandra

In: Antibiotics, 2020, vol. 9, no. 5, p. 21 p

The application of various isonitrile-based multicomponent reactions to protected (2-oxoethyl)boronic acid (as the carbonyl component) is described. The Ugi reaction, both in the four components and in the four centers–three components versions, and the van Leusen reaction, proved effective at providing small libraries of MIDA-protected β-aminoboronic acids. The corresponding free...

Université de Fribourg

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

Kvainickas, Arunas ; Nägele, Heike ; Qi, Wenjing ; Dokládal, Ladislav ; Jimenez-Orgaz, Ana ; Stehl, Luca ; Gangurde, Dipak ; Zhao, Qian ; Hu, Zehan ; Dengjel, Jörn ; Virgilio, Claudio De ; Baumeister, Ralf ; Steinberg, Florian

In: The Journal of Cell Biology, 2019, vol. 218, no. 9, p. 3019–3038

Retromer is an evolutionarily conserved multiprotein complex that orchestrates the endocytic recycling of integral membrane proteins. Here, we demonstrate that retromer is also required to maintain lysosomal amino acid signaling through mTORC1 across species. Without retromer, amino acids no longer stimulate mTORC1 translocation to the lysosomal membrane, which leads to a loss of mTORC1...

Consortium of Swiss Academic Libraries

The dietary protein, IGF-I, skeletal health axis

Bonjour, Jean-Philippe

In: Hormone Molecular Biology and Clinical Investigation, 2016, vol. 28, no. 1, p. 39-53