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Université de Fribourg

The rise of angiosperms pushed conifers to decline during global cooling

Condamine, Fabien L. ; Silvestro, Daniele ; Koppelhus, Eva B. ; Antonelli, Alexandre

In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 46, p. 28867–28875

Competition among species and entire clades can impact species diversification and extinction, which can shape macroevolutionary patterns. The fossil record shows successive biotic turnovers such that a dominant group is replaced by another. One striking example involves the decline of gymnosperms and the rapid diversification and ecological dominance of angiosperms in the Cretaceous. It is...

Université de Fribourg

Regional variation in hip and knee arthroplasty rates in Switzerland: A population-based small area analysis

Wertli, Maria M. ; Schlapbach, Judith M. ; Haynes, Alan G. ; Scheuter, Claudia ; Jegerlehner, Sabrina N. ; Panczak, Radoslaw ; Chiolero, Arnaud ; Rodondi, Nicolas ; Aujesky, Drahomir

In: PLOS ONE, 2020, vol. 15, no. 9, p. e0238287

Compared to other OECD countries, Switzerland has the highest rates of hip (HA) and knee arthroplasty (KA).Objective: We assessed the regional variation in HA/KA rates and potential determinants of variation in Switzerland.Methods: We conducted a population-based analysis using discharge data from all Swiss hospitals during 2013– 2016. We derived hospital service areas (HSAs) by analyzing...

Università della Svizzera italiana

Explaining the microtubule energy balance : contributions due to dipole moments, charges, van der Waals and solvation energy

Ayoub, Ahmed Taha ; Staelens, Michael ; Prunotto, Alessio ; Deriu, Marco A. ; Danani, Andrea ; Klobukowski, Mariusz ; Tuszynski, Jack Adam

In: International journal of molecular sciences, 2017, vol. 18, no. 10, p. 2042

Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization and depolymerization phases. This in turn is driven by a precise balance between attraction and repulsion forces between the constituents of...

Università della Svizzera italiana

Insights into the effect of the G245S single point mutation on the structure of p53 and the binding of the protein to DNA

Lepre, Marco Gaetano ; Omar, Sara Ibrahim ; Grasso, Gianvito ; Morbiducci, Umberto ; Deriu, Marco Agostino ; Tuszynski, Jack A.

In: Molecules, 2017, vol. 22, no. 8, p. 1358

The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the genome” because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority are missense mutations located in the DNA binding region. Among them, G245S is known to be...

Università della Svizzera italiana

Conformational dynamics and stability of U-shaped and S-shaped amyloid β assemblies

Grasso, Gianvito ; Rebella, Martina ; Muscat, Stefano ; Morbiducci, Umberto ; Tuszynski, Jack ; Danani, Andrea ; Deriu, Marco A.

In: International journal of molecular sciences, 2018, vol. 19, no. 2, p. 571

Alzheimer’s disease is the most fatal neurodegenerative disorder characterized by the aggregation and deposition of Amyloid β (Aβ) oligomers in the brain of patients. Two principal variants of Aβ exist in humans: Aβ1–40 and Aβ1–42. The former is the most abundant in the plaques, while the latter is the most toxic species and forms fibrils more rapidly. Interestingly, fibrils of...

Università della Svizzera italiana

A novel interaction between the TLR7 and a colchicine derivative revealed through a computational and experimental study

Gentile, Francesco ; Deriu, Marco A. ; Barakat, Khaled ; Danani, Andrea ; Tuszynski, Jack

In: Pharmaceuticals, 2018, vol. 11, no. 1, p. 22

The Toll-Like Receptor 7 (TLR7) is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837) and resiquimod (R-848). Recently, an interaction between R-837 and the colchicine binding site of tubulin was reported. To investigate the possibility of an interaction between...

Université de Fribourg

Notes on the cheek region of the Late Jurassic theropod dinosaur Allosaurus

Evers, Serjoscha W. ; Foth, Christian ; Rauhut, Oliver W.M.

In: PeerJ, 2020, vol. 8, p. e8493

Allosaurus, from the Late Jurassic of North America and Europe, is a model taxon for Jurassic basal tetanuran theropod dinosaurs. It has achieved an almost iconic status due to its early discovery in the late, 19th century, and due to the abundance of material from the Morrison Formation of the western U.S.A., making Allosaurus one of the best-known theropod taxa. Despite this, various...

Université de Fribourg

Late Jurassic theropod dinosaur bones from the Langenberg Quarry (Lower Saxony, Germany) provide evidence for several theropod lineages in the central European archipelago

Evers, Serjoscha W. ; Wings, Oliver

In: PeerJ, 2020, vol. 8, p. e8437

Marine limestones and marls in the Langenberg Quarry provide unique insights into a Late Jurassic island ecosystem in central Europe. The beds yield a varied assemblage of terrestrial vertebrates including extremely rare bones of theropod from theropod dinosaurs, which we describe here for the first time. All of the theropod bones belong to relatively small individuals but represent a wide...

Université de Fribourg

A non-archaeopterygid avialan theropod from the Late Jurassic of southern Germany

Rauhut, Oliver W. M. ; Tischlinger, Helmut ; Foth, Christian

In: eLife, 2019, vol. 8, p. e43789

The Late Jurassic ‘Solnhofen Limestones’ are famous for their exceptionally preserved fossils, including the urvogel Archaeopteryx, which has played a pivotal role in the discussion of bird origins. Here we describe a new, non-archaeopterygid avialan from the Lower Tithonian Mörnsheim Formation of the Solnhofen Archipelago, Alcmonavis poeschli gen. et sp. nov. Represented by a right...