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Université de Fribourg

The Co-evolution of Public Relations and Journalism : a First Contribution to Its Systematic Review = Ko-Evolution von Public Relations und Journalismus: Ein erster Beitrag zu ihrer systematischen Aufarbeitung

Schönhagen, Philomen ; Meissner, Mike

In: Public Relations Review, 2016, vol. 42, p. 748-758

There are many research findings and some theoretical models regarding the interaction between journalism and public relations (PR). But only scarce research has been done so far on the historical perspective of this relationship, which is also called co-evolution of PR and journalism. The aim of this article is to make a first step into the analysis of this co-evolution with a focus on the...

Université de Fribourg

Evolution of a Field : Swiss Media and Communication Studies

Probst, Carole ; Buhmann, Alexander ; Ingenhoff, Diana ; Lepori, Benedetto

In: Studies in Communication Sciences, 2019, vol. 19, no. 1, p. 7-23

In this paper, we present the evolution of Swiss Media and Communication Studies over the last decade by summarizing the main results from a project funded by the Swiss University Conference (2008–2017). We give an overall picture of the growth in the field (in terms of student numbers, resources and activities), look at diversity in terms of topics (two clusters are identified and ...

Université de Fribourg

Phosphorylation and circadian molecular timing

Brenna, Andrea ; Albrecht, Urs

In: Frontiers in Physiology, 2020, vol. 11, p. -

Endogenous circadian rhythms are biological processes generated by an internal body clock. They are self-sustaining, and they govern biochemical and physiological processes. However, circadian rhythms are influenced by many external stimuli to reprogram the phase in response to environmental change. Through their adaptability to environmental changes, they synchronize physiological responses...

Université de Fribourg

The past and future human impact on mammalian diversity

Andermann, Tobias ; Faurby, Søren ; Turvey, Samuel T. ; Antonelli, Alexandre ; Silvestro, Daniele

In: Science Advances, 2020, vol. 6, no. 36, p. eabb2313

To understand the current biodiversity crisis, it is crucial to determine how humans have affected biodiversity in the past. However, the extent of human involvement in species extinctions from the Late Pleistocene onward remains contentious. Here, we apply Bayesian models to the fossil record to estimate how mammalian extinction rates have changed over the past 126,000 years, inferring...

Université de Fribourg

Multiple cryoinjuries modulate the efficiency of zebrafish heart regeneration

Bise, Thomas ; Sallin, Pauline ; Pfefferli, Catherine ; Jaźwińska, Anna

In: Scientific Reports, 2020, vol. 10, no. 1, p. 11551

Zebrafish can regenerate their damaged hearts throughout their lifespan. It is, however, unknown, whether regeneration remains effective when challenged with successive cycles of cardiac damage in the same animals. Here, we assessed ventricular restoration after two, three and six cryoinjuries interspaced by recovery periods. Using transgenic cell-lineage tracing analysis, we demonstrated...

Université de Fribourg

Cystathionine-β-synthase: molecular regulation and pharmacological inhibition

Zuhra, Karim ; Augsburger, Fiona ; Majtan, Tomas ; Szabo, Csaba

In: Biomolecules, 2020, vol. 10, no. 5, p. 697

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (a cytotoxic molecule and cardiovascular risk factor) and the generation of hydrogen sulfide (H2S), a gaseous biological mediator with...

Université de Fribourg

Life-history evolution and the genetics of fitness components in drosophila melanogaster

Flatt, Thomas

In: Genetics, 2020, vol. 214, no. 1, p. 3–48

Life-history traits or “fitness components”—such as age and size at maturity, fecundity and fertility, age-specific rates of survival, and life span—are the major phenotypic determinants of Darwinian fitness. Analyzing the evolution and genetics of these phenotypic targets of selection is central to our understanding of adaptation. Due to its simple and rapid life cycle, cosmopolitan...

Université de Fribourg

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

Brenna, Andrea ; Olejniczak, Iwona ; Chavan, Rohit ; Ripperger, Jürgen A. ; Langmesser, Sonja ; Cameroni, Elisabetta ; Hu, Zehan ; De Virgilio, Claudio ; Dengjel, Jörn ; Albrecht, Urs

In: eLife, 2019, vol. 8, p. e50925

Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here, we show that the cyclin-dependent kinase 5...

Università della Svizzera italiana

ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress

Loi, Marisa ; Raimondi, Andrea ; Morone, Diego ; Molinari, Maurizio

In: Nature communications, 2019, vol. 10, p. 5058

The endoplasmic reticulum (ER) produces about 40% of the nucleated cell’s proteome. ER size and content in molecular chaperones increase upon physiologic and pathologic stresses on activation of unfolded protein responses (UPR). On stress resolution, the mammalian ER is remodeled to pre-stress, physiologic size and function on activation of the LC3-binding activity of the translocon...