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Université de Fribourg

A new glirid-like cricetid from the lower Oligocene of Southern China

Lu, Xiao-Yu ; Ni, Xijun ; Maridet, Olivier

In: Journal of Vertebrate Paleontology, 2021, p. e1917587

Here we report a new cricetid s.l., Caecocricetodon yani, gen. et sp. nov., discovered in the early Oligocene of the Caijiachong Formation in Yunnan Province, China. The new cricetid differs from all known cricetids or stem muroids by its particular molar pattern displaying numerous crests and spurs. Our phylogenetic analysis based on a matrix including 42 taxa and 72 characters indicates...

Université de Fribourg

New data on early Oligocene dormice (Rodentia, Gliridae) from southern Europe : Phylogeny and diversification of the family

Lu, Xiaoyu ; Costeur, Loïc ; Hugueney, Marguerite ; Maridet, Olivier

In: Journal of Systematic Palaeontology, 2021, p. 1-21

Rodents of the extant family Gliridae, commonly called dormice, are common in European faunas since the early Eocene. Here we study for the first time specimens from St-Martin-de-Castillon C (France, early Oligocene) previously reported as Gliravus aff. majori and Pseudodryomys aff. fugax. We now refer them to Butseloglis tenuis and Microdyromys misonnei. Besides the French material, new...

Université de Fribourg

CO and CO-releasing molecules in medicinal chemistry

Zobi, Fabio

In: Future Medicinal Chemistry, 2013, vol. 5, no. 2, p. 175-188

Since the discovery that CO acts as a cytoprotective and homeostatic molecule, increasing research efforts have been devoted to the exploitation of its therapeutic effects. Both endogenous and exogenous CO improves experimental lung, vascular and cardiac injuries and protects against several inflammatory states. The technology is now in place to bring CO to clinical applications, but the use...

Université de Fribourg

Glacier runoff variations since 1955 in the Maipo River basin, in the semiarid Andes of central Chile

Ayala, Álvaro ; Farías-Barahona, David ; Huss, Matthias ; Pellicciotti, Francesca ; McPhee, James ; Farinotti, Daniel

In: The Cryosphere, 2020, vol. 14, no. 6, p. 2005–2027

As glaciers adjust their size in response to climate variations, long-term changes in meltwater production can be expected, affecting the local availability of water resources. We investigate glacier runoff in the period 1955–2016 in the Maipo River basin (4843 km2, 33.0–34.3∘ S, 69.8–70.5∘ W), in the semiarid Andes of Chile. The basin contains more than 800 glaciers, which...

Université de Fribourg

Anchitheriinae (Perissodactyla, Equidae) from the early middle Miocene locality Gračanica (Bugojno Basin, Bosnia-Herzegovina)

Becker, Damien ; Tissier, Jérémy ; Vasilyan, Davit ; Göhlich, Ursula B.

In: Palaeobiodiversity and Palaeoenvironments, 2020, p. -

The early middle Miocene (European Land Mammal Zone MN5-earliest MN6) locality Gračanica (Bugojno Basin, Bosnia-Herzegovina) has yielded numerous well-preserved dental remains of two Anchitheriinae species: Anchitherium hippoides and Anchitherium ezquerrae. This anchithere assemblage is typical of the Orleanian European Land Mammal Age and is recorded for the first time in Southeastern...

Università della Svizzera italiana

How computational chemistry and drug delivery techniques can support the development of new anticancer drugs

Garofalo, Mariangela ; Grazioso, Giovanni ; Cavalli, Andrea ; Sgrignani, Jacopo

In: Molecules, 2020, vol. 25, no. 7, p. 22 p

The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems....

Université de Fribourg

Fish, amphibian and reptilian faunas from latest Oligocene to middle Miocene localities from Central Turkey

Vasilyan, Davit ; Roček, Zbyněk ; Ayvazyan, Anna ; Claessens, Leon

In: Palaeobiodiversity and Palaeoenvironments, 2019, vol. 99, no. 4, p. 723–757

In this paper, we describe ectothermic vertebrate assemblages from the Kargı 1, Kargı 2, Kargı 3, Harami1, Harami 3, Hancılı, Keseköy, Çandır and Bağiçi localities in Turkey. The ages of these localities range from the latest Oligocene to the middle Miocene. The preserved non-mammalian fauna of the studied localities includes fishes (Luciobarbus sp., Barbus sp., Luciobarbus vel...