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Università della Svizzera italiana

Thyroid sequelae of COVID-19 : a systematic review of reviews

Trimboli, Pierpaolo ; Camponovo, Chiara ; Scappaticcio, Lorenzo ; Bellastella, Giuseppe ; Piccardo, Arnoldo ; Rotondi, Mario

In: Reviews in Endocrine and Metabolic Disorders, 2021, vol. 22, no. 2, p. 485-491

The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the potential to cause multi- organ effects including endocrine disorders. The impact of COVID-19 on the thyroid gland has been described but several aspects have to be clarified. The systematic review was conceived to achieve more solid information about: 1) which thyroid...

Haute Ecole de Gestion & Tourisme

Data mining in Bioprocesses – Knowledge discovery in databases (IIG part)

Artero, Christopher ; Schumann, René (Dir.)

Mémoire de bachelor : Haute Ecole de Gestion & Tourisme, 2021.

The purpose of this thesis is to create clusters from historical data with and without domain knowledge. The method used to cluster the data with domain knowledge is a pattern matching sequence and the method done without domain knowledge is a clustering algorithm that will be defined later. The data had to be retrieved from four old databases, then prepared to be clustered. A...

Università della Svizzera italiana

Macrophage death following influenza vaccination initiates the inflammatory response that promotes dendritic cell function in the draining lymph node

Chatziandreou, Nikolaos ; Farsakoglu, Yagmur ; Palomino-Segura, Miguel ; D’Antuono, Rocco ; Pizzagalli, Diego Ulisse ; Sallusto, Federica ; Lukacs-Kornek, Veronika ; Uguccioni, Mariagrazia ; Corti, Davide ; Turley, Shannon J. ; Lanzavecchia, Antonio ; Carroll, Michael C. ; Gonzalez, Santiago F.

In: Cell reports, 2017, vol. 18, no. 10, p. 2427-2440

The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vaccine. Following vaccination, LNMs undergo inflammasome-independent necrosis-like death that is reliant on MyD88 and Toll-like receptor 7 (TLR7)...