In: Journal of Molecular Cell Biology, 2016, vol. 8, no. 1, p. 62-72
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In: Journal of Biomolecular NMR, 2015, vol. 63, no. 1, p. 21-37
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In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 3, p. -
Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315),...
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In: Molecules, 2017, vol. 22, no. 8, p. 1358
The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the genome” because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority are missense mutations located in the DNA binding region. Among them, G245S is known to be...
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In: Accounts of Chemical Research, 2019, vol. 52, no. 11, p. 3087–3096
The regulatory chemical mechanisms of lipid trafficking and degradation are involved in many pathophysiological processes, being implicated in severe pain, inflammation, and cancer. In addition, the processing of lipids is also relevant for industrial and environmental applications. However, there is poor understanding of the chemical features that control lipid membrane trafficking and allow...
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In: Plos one, 2014, vol. 9, no. 7, p. e102658
In this manuscript, we modulate the binding properties of estrogen receptor protein by rationally modifying the amino acid composition of its ligand binding domain. By combining sequence alignment and structural analysis of known estrogen receptor- ligand complexes with computational analysis, we were able to predict estrogen receptor mutants with altered binding properties. These predictions...
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In: JBIC Journal of Biological Inorganic Chemistry, 2014, vol. 19, no. 4-5, p. 565-575
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In: European Biophysics Journal, 2014, vol. 43, no. 2-3, p. 113-119
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In: Journal of Molecular Evolution, 2010, vol. 70, no. 4, p. 313-324
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In: Journal of Molecular Evolution, 2013, vol. 76, no. 5, p. 343-349
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