In: Clinical Chemistry and Laboratory Medicine (CCLM), 2017, vol. 55, no. 12, p. 1873-1880
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In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 2, p. 385-391
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In: Expert Opinion on Drug Delivery, 2020, vol. 17, no. 4, p. 463–478
Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in- silico to in-vitro, ex–vivo and in-vivo, can be implemented.Areas covered: The present review covers in-silico mathematical and computational...
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In: Journal of Clinical Microbiology, 2020, vol. 58, no. 9, p. -
The SuperCAZ/AVI medium was developed for screening ceftazidime-avibactam (CZA) resistance among Gram-negative bacteria (Enterobacterales and Pseudomonas aeruginosa). It was evaluated using 50 CZA-susceptible and 42 CZA- resistant Gram-negative isolates. Its sensitivity and specificity of detection were 100%. Excellent performance of the medium was also observed by testing spiked stools, with ...
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In: Diagnostic Microbiology and Infectious Disease, 2020, vol. 98, no. 2, p. 115121
Carbapenem-resistant Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA), as well as polymyxin-resistant A. baumannii (PMR-AB) and P. aeruginosa (PMR-PA), were used to test different enrichment strategies from spiked stools. Three procedures were compared, namely, direct inoculation on selective plates and plating after a 24-h enrichment step in tryptic soy broth with or without ...
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In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 7, p. -
Many transferable quinolone resistance mechanisms have been identified in Gram- negative bacteria. The plasmid-encoded 65-amino-acid-long ciprofloxacin-modifying enzyme CrpP was recently identified in Pseudomonas aeruginosa isolates. We analyzed a collection of 100 clonally unrelated and multidrug-resistant P. aeruginosa clinical isolates, among which 46 were positive for crpP-like genes,...
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In: European Journal of Clinical Microbiology & Infectious Diseases, 2020, p. -
Polymyxins are becoming an added value for treating infections due to multidrug-resistant Pseudomonas aeruginosa. Therefore, the Rapid Polymyxin/Pseudomonas NP test was developed for the identification of polymyxin resistance in P. aeruginosa isolates. This test detects the bacterial growth in a medium containing a defined concentration of colistin. Formation of basic metabolites is visually...
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In: Developmental Cell, 2019, vol. 50, no. 6, p. 780-792.e7
Size trade-offs of visual versus olfactory organs is a pervasive feature of animal evolution. This could result from genetic or functional constraints. We demonstrate that head sensory organ size trade-offs in Drosophila are genetically encoded and arise through differential subdivision of the head primordium into visual versus non- visual fields. We discover that changes in the temporal...
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In: Journal of Antimicrobial Chemotherapy, 2019, vol. 74, no. 7, p. 1934–1939
To evaluate the efficacy of the recently launched β-lactam/β-lactamase inhibitor combinations ceftazidime/avibactam and ceftolozane/tazobactam against ESBL- producing Escherichia coli and Pseudomonas aeruginosa strains.Methods: A series of ESBL-encoding genes (blaTEM, blaSHV, blaCTX-M, blaVEB, blaPER, blaGES and blaBEL) was cloned and expressed in E. coli or P. aeruginosa recipient strains. ...
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In: Osteoporosis International, 2014, vol. 25, no. 11, p. 2531-2531
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