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Crossover or non-crossover outcomes : tailored processing of homologous recombination intermediates

Sanchez, Aurore ; Reginato, Giordano ; Cejka, Petr

In: Current opinion in genetics & development, 2021, vol. 71, p. 39-47

DNA breaks may arise accidentally in vegetative cells or in a programmed manner in meiosis. The usage of a DNA template makes homologous recombination potentially error-free, however, recombination is not always accurate. Cells possess a remarkable capacity to tailor processing of recombination intermediates to fulfill a particular need. Vegetatively growing cells aim to maintain genome...

An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models

Fagiani, Ernesta ; Bill, Ruben ; Pisarsky, Laura ; Ivanek, Robert ; Rüegg, Curzio ; Christofori, Gerhard

In: Angiogenesis, 2015, vol. 18, no. 3, p. 327-345

Whole genome sequencing as a means to assess pathogenic mutations in medical genetics and cancer

Royer-Bertrand, Beryl ; Rivolta, Carlo

In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 8, p. 1463-1471

Tumor budding in colorectal cancer revisited: results of a multicenter interobserver study

Koelzer, Viktor ; Zlobec, Inti ; Berger, Martin ; Cathomas, Gieri ; Dawson, Heather ; Dirschmid, Klaus ; Hädrich, Marion ; Inderbitzin, Daniel ; Offner, Felix ; Puppa, Giacomo ; Seelentag, Walter ; Schnüriger, Beat ; Tornillo, Luigi ; Lugli, Alessandro

In: Virchows Archiv, 2015, vol. 466, no. 5, p. 485-493

Discrete Improvement in Racial Disparity in Survival among Patients with Stage IV Colorectal Cancer: a 21-Year Population-Based Analysis

Castleberry, A. ; Güller, U. ; Tarantino, I. ; Berry, M. ; Brügger, L. ; Warschkow, R. ; Cerny, T. ; Mantyh, C. ; Candinas, D. ; Worni, M.

In: Journal of Gastrointestinal Surgery, 2014, vol. 18, no. 6, p. 1194-1204

Characterization and in vivo validation of a three-dimensional multi-cellular culture model to study heterotypic interactions in colorectal cancer cell growth, invasion and metastasis

Cattin, Sarah ; Ramont, Laurent ; Rüegg, Curzio

In: Frontiers in Bioengineering and Biotechnology, 2018, vol. 6, p. -

Colorectal cancer (CRC) is the third cause of cancer-related mortality in industrialized countries. Local invasion and metastasis formation are events associated with poor prognosis for which today there are no effective therapeutic options. Invasion and metastasis are strongly modulated by cells of the tumor microenvironment (TME), in particular fibroblasts and endothelial cells. Unraveling...

Arthrogryposis multiplex congenita (AMC), a hereditary disease in swine, maps to Chromosome 5 by linkage analysis

Genini, Sem ; Malek, Massoud ; Špilar, Špela ; Nguyen, Trung ; Ménétrey, Frédéric ; Gebert, Stefen ; Hagger, Christian ; Neuenschwander, Stefan ; Kadarmideen, Haja ; Stranzinger, Gerald ; Vögeli, Peter

In: Mammalian Genome, 2004, vol. 15, no. 11, p. 935-941

Effects of phenotypes in heterocyclic aromatic amine (HCA) metabolism-related genes on the association of HCA intake with the risk of colorectal adenomas

Barbir, Aline ; Linseisen, Jakob ; Hermann, Silke ; Kaaks, Rudolf ; Teucher, Birgit ; Eichholzer, Monika ; Rohrmann, Sabine

In: Cancer Causes & Control, 2012, vol. 23, no. 9, p. 1429-1442

Diagnostic accuracy of C-reactive protein and white blood cell counts in the early detection of inflammatory complications after open resection of colorectal cancer: a retrospective study of 1,187 patients

Warschkow, Rene ; Tarantino, Ignazio ; Torzewski, Michael ; Näf, Franziska ; Lange, Jochen ; Steffen, Thomas

In: International Journal of Colorectal Disease, 2011, vol. 26, no. 11, p. 1405-1413

Evidence for genetic anticipation in hereditary non-polyposis colorectal cancer

Westphalen, Alexander ; Russell, Anna ; Buser, Mauro ; Berthod, Claudine ; Hutter, Pierre ; Plasilova, Martina ; Mueller, Hansjakob ; Heinimann, Karl

In: Human Genetics, 2005, vol. 116, no. 6, p. 461-465