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Università della Svizzera italiana

Block-enhanced precision matrix estimation for large-scale datasets

Eftekhari, Aryan ; Pasadakis, Dimosthenis ; Bollhöfer, Matthias ; Scheidegger, Simon ; Schenk, Olaf

In: Journal of computational science, 2021, vol. 53, p. 13

The ℓ1-regularized Gaussian maximum likelihood method is a common approach for sparse precision matrix estimation, but one that poses a computational challenge for high-dimensional datasets. We present a novel ℓ1- regularized maximum likelihood method for performant large-scale sparse precision matrix estimation utilizing the block structures in the underlying computations. We identify the...

Université de Fribourg

Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance

Stolp, Bettina ; Thelen, Flavian ; Ficht, Xenia ; Altenburger, Lukas M. ; Ruef, Nora ; Inavalli, V. V. G. Krishna ; Germann, Philipp ; Page, Nicolas ; Moalli, Federica ; Raimondi, Andrea ; Keyser, Kirsten A. ; Jafari, S. Morteza Seyed ; Barone, Francesca ; Dettmer, Matthias S. ; Merkler, Doron ; Iannacone, Matteo ; Sharpe, James ; Schlapbach, Christoph ; Fackler, Oliver T. ; Nägerl, U. Valentin ; Stein, Jens V.

In: Science Immunology, 2020, vol. 5, no. 46, p. eaaz4371

It is well established that tissue macrophages and tissue-resident memory CD8+ T cells (TRM) play important roles for pathogen sensing and rapid protection of barrier tissues. In contrast, the mechanisms by which these two cell types cooperate for homeostatic organ surveillance after clearance of infections is poorly understood. Here, we used intravital imaging to show that TRM dynamically...

Consortium of Swiss Academic Libraries

Legal and illegal immigrants: an analysis of optimal saving behavior

Vinogradova, Alexandra

In: Journal of Population Economics, 2014, vol. 27, no. 1, p. 201-224

Consortium of Swiss Academic Libraries

Reelection threshold contracts in politics

Gersbach, Hans ; Liessem, Verena

In: Social Choice and Welfare, 2008, vol. 31, no. 2, p. 233-255

Consortium of Swiss Academic Libraries

Fairness and voting

Hahn, Volker

In: Social Choice and Welfare, 2007, vol. 28, no. 4, p. 591-605