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Université de Fribourg

Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Janickova, Lucia ; Rechberger, Karin Farah ; Wey, Lucas ; Schwaller, Beat

In: Molecular Autism, 2020, vol. 11, no. 1, p. 47

In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delayed Ca2+ sequestering/buffering. An inverse regulation of PV and mitochondria likewise operates in cell model...

Université de Fribourg

Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep

Gutierrez Herrera, C. ; Girard, Franck ; Bilella, Alessandro ; Gent, T. C. ; Roccaro-Waldmeyer, Diana M. ; Adamantidis, A. ; Celio, Marco R.

In: Nature Communications, 2019, vol. 10, no. 1, p. 1–11

Rapid eye movements (REM) are characteristic of the eponymous phase of sleep, yet the underlying motor commands remain an enigma. Here, we identified a cluster of Calbindin-D28K-expressing neurons in the Nucleus papilio (NPCalb), located in the dorsal paragigantocellular nucleus, which are active during REM sleep and project to the three contralateral eye-muscle nuclei. The firing of...

Consortium of Swiss Academic Libraries

Glycine-induced neurotoxicity in organotypic hippocampal slice cultures

Barth, A. ; Nguyen, L. ; Barth, L. ; Newell, D.

In: Experimental Brain Research, 2005, vol. 161, no. 3, p. 351-357