In: Non-coding RNA, 2021, vol. 7, no. 2, p. 13
Stressful conditions induce the cell to save energy and activate a rescue program modulated by mammalian target of rapamycin (mTOR). Along with transcriptional and translational regulation, the cell relies also on post-transcriptional modulation to quickly adapt the translation of essential proteins. MicroRNAs play an important role in the regulation of protein translation, and their...
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In: Oncogene, 2021, vol. 40, no. 7, p. 1205–1216
Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens have emerged and have been successfully i mplemented in clinical practice. That said, the stronger inhibition of the AR signaling axis has led in recent years to an increase of prostate cancers that de-differentiate...
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In: Archives of Gynecology and Obstetrics, 2015, vol. 291, no. 6, p. 1387-1394
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In: Human Reproduction Update, 2016, vol. 22, no. 3, p. 382-403
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In: Journal of Molecular Medicine, 2015, vol. 93, no. 10, p. 1061-1073
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In: Cardiovascular Research, 2016, vol. 109, no. 1, p. 103-114
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In: Hormone Molecular Biology and Clinical Investigation, 2017, vol. 32, no. 1, p. -
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In: Breast Cancer Research and Treatment, ///-
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In: Cancers, 2020, vol. 12, no. 10, p. 23 p
Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks effective therapeutic options. In this study, we profile eighteen TNBC cell lines for their sensitivity to the anti-proliferative action of all-trans retinoic acid (ATRA). The only three cell lines (HCC-1599, MB- 157 and MDA-MB-157) endowed with ATRA-sensitivity are characterized by genetic aberrations of the NOTCH1-gene,...
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In: Cancers, 2020, vol. 12, no. 3, p. 532
Poly(ADP-ribose) polymerase (PARP) inhibitors have recently been introduced in the therapy of several types of cancers not responding to conventional treatments. However, de novo and acquired PARP inhibitor resistance is a significant limiting factor in the clinical therapy, and the underlying mechanisms are not fully understood. Activity of the cytoprotective phosphatidylinositol-3 kinase...
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