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Consortium of Swiss Academic Libraries

Genomic medicine at the heart of diabetes management

McCarthy, Mark

In: Diabetologia, 2015, vol. 58, no. 8, p. 1725-1729

Università della Svizzera italiana

Modulation of chemokine responses : synergy and cooperativity

Proudfoot, Amanda E.I. ; Uguccioni, Mariagrazia

In: Frontiers in immunology, 2016, vol. 7, p. 183

Chemokine biology is mediated by more complex interactions than simple monomolecular ligand–receptor interactions, as chemokines can form higher order quaternary structures, which can also be formed after binding to glycosaminoglycans (GAGs) on endothelial cells, and their receptors are found as dimers and/or oligomers at the cell surface. Due to the complexity of the chemokine binding and...

Università della Svizzera italiana

Potential of PEGylated toll-like receptor 7 ligands for controlling inflammation and functional changes in mouse models of asthma and silicosis

Teixeira Ferreira, Tatiana Paula ; Lacerda Mariano, Lívia ; Ghilosso-Bortolini, Roberta ; Santos de Arantes, Ana Carolina ; Fernandes, Andrey Junior ; Berni, Michelle ; Cecchinato, Valentina ; Uguccioni, Mariagrazia ; Maj, Roberto ; Barberis, Alcide ; Machado Rodrigues Silva, Patricia ; Martins, Marco Aurélio

In: Frontiers in immunology, 2016, vol. 7, p. 95

Prior investigations show that signaling activation through pattern recognition receptors can directly impact a number of inflammatory lung diseases. While toll-like receptor (TLR) 7 agonists have raised interest for their ability to inhibit allergen-induced pathological changes in experimental asthma conditions, the putative benefit of this treatment is limited by adverse effects. Our aim...