Refine my results

Dietary chloride deficiency syndrome : pathophysiology, history, and systematic literature review

Signorelli, Giulia C. ; Bianchetti, Mario G. ; Jermini, Luca M. M. ; Agostoni, Carlo ; Milani, Gregorio P. ; Simonetti, Giacomo D. ; Lava, Sebastiano A. G.

In: Nutrients, 2020, vol. 12, no. 11, p. 10 p

Metabolic alkalosis may develop as a consequence of urinary chloride (and sodium) wasting, excessive loss of salt in the sweat, or intestinal chloride wasting, among other causes. There is also a likely underrecognized association between poor salt intake and the mentioned electrolyte and acid–base abnormality. In patients with excessive loss of salt in the sweat or poor salt intake, the...

Dietary potassium and the renal control of salt balance and blood pressure

Penton, David

In: Pflügers Archiv : European Journal of Physiology, ///-

ENaC activity in collecting ducts modulates NCC in cirrhotic mice

Mordasini, David ; Loffing-Cueni, Dominique ; Loffing, Johannes ; Beatrice, Rohrbach ; Maillard, Marc ; Hummler, Edith ; Burnier, Michel ; Escher, Geneviève ; Vogt, Bruno

In: Pflügers Archiv - European Journal of Physiology, 2015, vol. 467, no. 12, p. 2529-2539

Intercalation of graphene on iridium with sodium atoms

Rut'kov, E. ; Gall', N.

In: Physics of the Solid State, 2015, vol. 57, no. 6, p. 1249-1252

Salt intake in children and its consequences on blood pressure

Lava, Sebastiano ; Bianchetti, Mario ; Simonetti, Giacomo

In: Pediatric Nephrology, 2015, vol. 30, no. 9, p. 1389-1396

Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Janickova, Lucia ; Rechberger, Karin Farah ; Wey, Lucas ; Schwaller, Beat

In: Molecular Autism, 2020, vol. 11, no. 1, p. 47

In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delayed Ca2+ sequestering/buffering. An inverse regulation of PV and mitochondria likewise operates in cell model...

Granzyme B attenuates bacterial virulence by targeting secreted factors

López León, Diego ; Matthey, Patricia ; Fellay, Isabelle ; Blanchard, Marianne ; Martinvalet, Denis ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: iScience, 2020, vol. 23, no. 3, p. 100932

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...

Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome

Larionov, Alexey ; Dahlke, Eileen ; Kunke, Madlen ; Rodriguez, Luis Zanon ; Schiessl, Ina M. ; Magnin, Jean‐Luc ; Kern, Ursula ; Alli, Abdel A. ; Mollet, Geraldine ; Schilling, Oliver ; Castrop, Hayo ; Theilig, Franziska

In: Journal of Cellular and Molecular Medicine, 2019, vol. 23, no. 10, p. 6543–6553

The NPHS2 gene, encoding the slit diaphragm protein podocin, accounts for genetic and sporadic forms of nephrotic syndrome (NS). Patients with NS often present symptoms of volume retention, such as oedema formation or hypertension. The primary dysregulation in sodium handling involves an inappropriate activation of the epithelial sodium channel, ENaC. Plasma proteases in a...

A primary culture system of mouse thick ascending limb cells with preserved function and uromodulin processing

Glaudemans, Bob ; Terryn, Sara ; Gölz, Nadine ; Brunati, Martina ; Cattaneo, Angela ; Bachi, Angela ; Al-Qusairi, Lama ; Ziegler, Urs ; Staub, Olivier ; Rampoldi, Luca ; Devuyst, Olivier

In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 2, p. 343-356

Renale Kontrolle der Kaliumhomöostase = Renal control of potassium homeostasis

Loffing, J.