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Université de Fribourg

Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions

Marques, Filipe ; Thapliyal, Saurabh ; Javer, Avelino ; Shrestha, Priyanka ; Brown, André E. X. ; Glauser, Dominique A.

In: PLOS Genetics, 2020, vol. 16, no. 10, p. e1009102

Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify...

Université de Fribourg

Towards deciphering variations of heart regeneration in fish

Jaźwińska, Anna ; Blanchoud, Simon

In: Current Opinion in Physiology, 2020, vol. 14, p. 21–26

Among adult vertebrates, the zebrafish presents the rather exceptional capacity to efficiently regenerate its heart after injury. This bony fish has thus become a leading genetic model organism to elucidate the natural mechanisms of successful cardiac restoration. Given its potential biomedical significance, parallel analyses between zebrafish and mammals are aiming at the identification of...

Consortium of Swiss Academic Libraries

Hepatic glucose sensing and integrative pathways in the liver

Oosterveer, Maaike ; Schoonjans, Kristina

In: Cellular and Molecular Life Sciences, 2014, vol. 71, no. 8, p. 1453-1467

Consortium of Swiss Academic Libraries

Immunological aspects of atherosclerosis

Garrido-Urbani, S. ; Meguenani, M. ; Montecucco, F. ; Imhof, B.

In: Seminars in Immunopathology, 2014, vol. 36, no. 1, p. 73-91

Consortium of Swiss Academic Libraries

Cholesterol Transport and Regulation in the Mammary Gland

Ontsouka, Edgar ; Albrecht, Christiane

In: Journal of Mammary Gland Biology and Neoplasia, 2014, vol. 19, no. 1, p. 43-58