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Detecting Alzheimer’s disease (AD) : from the asymptomatic stages of healthy adults with AD genetic disposition to late stages of severe neurocognitive impairment

Ibnidris, Aliaa ; Albanese, Emiliano (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2021 ; 2021BIOMED001.

Background: Dementia is a syndrome characterized by progressive cognitive impairment, psychological and behavioural symptoms, and functional deficits. It is one of the leading causes of disability worldwide; its impact and the associated costs are enormous. Consequently, dementia is a global public health priority, and so is Alzheimer’s disease (AD), the most common cause of dementia in late...

Mild Depressive Symptoms Mediate the Impact of Childhood Trauma on Long-Term Functional Outcome in Early Psychosis Patients

Alameda, Luis ; Golay, Philippe ; Baumann, Philipp S. ; Progin, Pierre ; Mebdouhi, Nadir ; Elowe, Julien ; Ferrari, Carina ; Do, Kim Q. ; Conus, Philippe

In: Schizophrenia Bulletin, 2017, vol. 43, no. 5, p. 1027-1035

Unipolar mania: a necessary diagnostic concept

Angst, Jules ; Grobler, Christoffel

In: European Archives of Psychiatry and Clinical Neuroscience, 2015, vol. 265, no. 4, p. 273-280

Evaluation of a New Person-Centered Integrated Care Model in Psychiatry

Theodoridou, Anastasia ; Hengartner, Michael ; Gairing, Stefanie ; Jäger, Matthias ; Ketteler, Daniel ; Kawohl, Wolfram ; Lauber, Christoph ; Rössler, Wulf

In: Psychiatric Quarterly, 2015, vol. 86, no. 2, p. 153-168

Classifying Intersex in DSM-5: Critical Reflections on Gender Dysphoria

Kraus, Cynthia

In: Archives of Sexual Behavior, 2015, vol. 44, no. 5, p. 1147-1163

Negative association between left prefrontal GABA concentration and BDNF serum concentration in young adults

Müller, Sabrina Theresia ; Buchmann, Andreas ; Haynes, Melanie ; Ghisleni, Carmen ; Ritter, Christopher ; Tuura, Ruth ; Hasler, Gregor

In: Heliyon, 2020, vol. 6, no. 5, p. e04025

The brain's major inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and the brain-derived neurotrophic factor (BDNF) play important roles in several stress- related disorders. Magnetic resonance spectroscopy (MRS) allows for non-invasive quantification of GABA concentration in the brain. We investigated the relationship between GABA concentration in the left dorsolateral prefrontal...

Affective cognition in bipolar disorder: A systematic review by the ISBD targeting cognition task force

Miskowiak, Kamilla W. ; Seeberg, Ida ; Kjaerstad, Hanne L. ; Burdick, Katherine E. ; Martinez‐Aran, Anabel ; Bonnin, Caterina del Mar ; Bowie, Christopher R. ; Carvalho, Andre F. ; Gallagher, Peter ; Hasler, Gregor ; Lafer, Beny ; López‐Jaramillo, Carlos ; Sumiyoshi, Tomiki ; McIntyre, Roger S. ; Schaffer, Ayal ; Porter, Richard J. ; Purdon, Scot ; Torres, Ivan J. ; Yatham, Lakshmi N. ; Young, Allan H. ; Kessing, Lars V. ; Rheenen, Tamsyn E. Van ; Vieta, Eduard

In: Bipolar Disorders, 2019, p. -

Background: Impairments in affective cognition are part of the neurocognitive profile and possible treatment targets in bipolar disorder (BD), but the findings are heterogeneous. The International Society of Bipolar Disorder (ISBD) Targeting Cognition Task Force conducted a systematic review to (i) identify the most consistent findings in affective cognition in BD, and (ii) provide...

Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy

Hasler, Gregor ; Buchmann, Andreas ; Haynes, Melanie ; Müller, Sabrina Theresia ; Ghisleni, Carmen ; Brechbühl, Sarela ; Tuura, Ruth

In: Translational Psychiatry, 2019, vol. 9, no. 1, p. 170

There is growing evidence for GABA and glutamate–glutamine dysfunction in the pathogenesis of mood and anxiety disorders. It is important to study this pathology in the early phases of the illness in order to develop new approaches to secondary prevention. New magnetic resonance spectroscopy (MRS) measures allow determining glutamine, the principal metabolite of synaptic glutamate that is...

Suicidality in the prospective Zurich study: prevalence, risk factors and gender

Angst, Jules ; Hengartner, Michael ; Rogers, Jonathan ; Schnyder, Ulrich ; Steinhausen, Hans-Christoph ; Ajdacic-Gross, Vladeta ; Rössler, Wulf

In: European Archives of Psychiatry and Clinical Neuroscience, 2014, vol. 264, no. 7, p. 557-565

Neural correlates of free T3 alteration after catecholamine depletion in subjects with remitted major depressive disorder and in controls

Homan, Philipp ; Drevets, Wayne ; Hasler, Gregor

In: Psychopharmacology, 2014, vol. 231, no. 2, p. 409-417