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Università della Svizzera italiana

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone

Pickett, Julie E. ; Thompson, John M. ; Sadowska, Agnieszka ; Tkaczyk, Christine ; Sellman, Bret R. ; Minola, Andrea ; Corti, Davide ; Lanzavecchia, Antonio ; Miller, Lloyd S. ; Thorek, Daniel LJ

In: Bone research, 2018, vol. 6, p. 13

Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody (mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid (LTA). Specificity and affinity were assessed in...

Università della Svizzera italiana

Therapeutic efficacy of antibodies lacking FcγR against lethal dengue virus infection is due to neutralizing potency and blocking of enhancing antibodies

Williams, Katherine L. ; Sukupolvi-Petty, Soila ; Beltramello, Martina ; Johnson, Syd ; Sallusto, Federica ; Lanzavecchia, Antonio ; Diamond, Michael S. ; Harris, Eva

In: Plos pathogens, 2013, vol. 9, no. 2, p. e1003157

Dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) are life-threatening complications following infection with one of the four serotypes of dengue virus (DENV). At present, no vaccine or antiviral therapies are available against dengue. Here, we characterized a panel of eight human or mouse-human chimeric monoclonal antibodies (MAbs) and their modified variants lacking effector...

Università della Svizzera italiana

Immunogenetic mechanisms driving norovirus GII.4 antigenic variation

Lindesmith, Lisa C. ; Beltramello, Martina ; Donaldson, Eric F. ; Corti, Davide ; Swanstrom, Jesica ; Debbink, Kari ; Lanzavecchia, Antonio ; Baric, Ralph S.

In: Plos pathogens, 2012, vol. 8, no. 5, p. e1002705

Noroviruses are the principal cause of epidemic gastroenteritis worldwide with GII.4 strains accounting for 80% of infections. The major capsid protein of GII.4 strains is evolving rapidly, resulting in new epidemic strains with altered antigenic potentials. To test if antigenic drift may contribute to GII.4 persistence, human memory B cells were immortalized and the resulting human monoclonal...

Consortium of Swiss Academic Libraries

Treatment of Primary CNS Lymphoma

Roth, Patrick ; Stupp, Roger ; Eisele, Günter ; Weller, Michael

In: Current Treatment Options in Neurology, 2014, vol. 16, no. 1, p. 1-14