In: Future Medicinal Chemistry, 2013, vol. 5, no. 2, p. 175-188
Since the discovery that CO acts as a cytoprotective and homeostatic molecule, increasing research efforts have been devoted to the exploitation of its therapeutic effects. Both endogenous and exogenous CO improves experimental lung, vascular and cardiac injuries and protects against several inflammatory states. The technology is now in place to bring CO to clinical applications, but the use...
|
In: Molecules, 2020, vol. 25, no. 16, p. 3739
Cystathionine β-synthase (CBS) is a key enzyme in the production of the signaling molecule hydrogen sulfide, deregulation of which is known to contribute to a range of serious pathological states. Involvement of hydrogen sulfide in pathways of paramount importance for cellular homeostasis renders CBS a promising drug target. An in-house focused library of heteroaromatic compounds was...
|
In: Topics in Catalysis, 2014, vol. 57, no. 14-16, p. 1256-1264
|
In: World Journal of Surgery, 2005, vol. 29, no. 6, p. 692-699
|
In: Molecular Diversity, 1997, vol. 2, no. 3, p. 171-174
|
In: Cellular and Molecular Life Sciences, 2012, vol. 69, no. 15, p. 2485-2499
|
In: Histochemistry and Cell Biology, 2003, vol. 120, no. 5, p. 353-360
|
In: Cardiovascular Research, 1994, vol. 28, no. 5, p. 604-609
|
In: Pure and Applied Chemistry, 2008, vol. 80, no. 3, p. 411-427
|
In: Inorganic Chemistry, 2011, vol. 50, no. 17, p. 8188–8196
A series of bimetallic N-heterocyclic carbene (NHC) ruthenium(II) complexes were synthesized, which comprise two [RuCl₂(cymene)(NHC)] units that are interlinked via the NHC nitrogens by alkyl chains of different length. Electrochemical characterization revealed two mutually dependent oxidation processes for the complex with a methylene linker, indicating moderate intramolecular electronic...
|