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Université de Fribourg

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Sønder, Stine Lauritzen ; Boye, Theresa Louise ; Tölle, Regine ; Dengjel, Jörn ; Maeda, Kenji ; Jäättelä, Marja ; Simonsen, Adam Cohen ; Jaiswal, Jyoti K. ; Nylandsted, Jesper

In: Scientific Reports, 2019, vol. 9, no. 1, p. 6726

The plasma membrane of eukaryotic cells forms the essential barrier to the extracellular environment, and thus plasma membrane disruptions pose a fatal threat to cells. Here, using invasive breast cancer cells we show that the Ca2+ - and phospholipid-binding protein annexin A7 is part of the plasma membrane repair response by enabling assembly of the endosomal sorting complex required for ...