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Uterine responses to early pre-attachment embryos in the domestic dog and comparisons with other domestic animal species†

Graubner, Felix R. ; Gram, Aykut ; Kautz, Ewa ; Bauersachs, Stefan ; Aslan, Selim ; Agaoglu, Ali R. ; Boos, Alois ; Kowalewski, Mariusz P.

In: Biology of Reproduction, 2017, vol. 97, no. 2, p. 197-216

An intensified training schedule in recreational male runners is associated with increases in erythropoiesis and inflammation and a net reduction in plasma hepcidin

Moretti, Diego ; Mettler, Samuel ; Zeder, Christophe ; Lundby, Carsten ; Geurts-Moetspot, Anneke ; Monnard, Arnaud ; Swinkels, Dorine W. ; Brittenham, Gary M. ; Zimmermann, Michael B.

In: The American Journal of Clinical Nutrition, 2018, vol. 108, no. 6, p. 1324-1333

Comparison of Sleep Disorders between Real and Simulated 3,450-m Altitude

Heinzer, Raphaël ; Saugy, Jonas J. ; Rupp, Thomas ; Tobback, Nadia ; Faiss, Raphael ; Bourdillon, Nicolas ; Rubio, José Haba ; Millet, Grégoire P.

In: Sleep, 2016, vol. 39, no. 8, p. 1517-1523

Effect of Exercise on Arterial Stiffness: Is There a Ceiling Effect?

Montero, David ; Breenfeldt-Andersen, Andreas ; Oberholzer, Laura ; Haider, Thomas

In: American Journal of Hypertension, 2017, vol. 30, no. 11, p. 1069-1072

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Orlando, Ilaria M. C. ; Lafleur, Véronique N. ; Storti, Federica ; Spielmann, Patrick ; Crowther, Lisa ; Santambrogio, Sara ; Schödel, Johannes ; Hoogewijs, David ; Mole, David R. ; Wenger, Roland H.

In: Haematologica, 2019, vol. 105, no. 12, p. 2774–2784

While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE located downstream of the EPO gene, but this 3' HRE is dispensable for renal EPO gene...

Hypoxia pathway proteins are master regulators of erythropoiesis

Watts, Deepika ; Gaete, Diana ; Rodriguez, Diego ; Hoogewijs, David ; Rauner, Martina ; Sormendi, Sundary ; Wielockx, Ben

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8131

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO- producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia);...

Compartment and cell-type specific hypoxia responses in the developing Drosophila brain

Baccino-Calace, Martin ; Prieto, Daniel ; Cantera, Rafael ; Egger, Boris

In: Biology Open, 2020, vol. 9, no. 8, p. -

Environmental factors such as the availability of oxygen are instructive cues that regulate stem cell maintenance and differentiation. We used a genetically encoded biosensor to monitor the hypoxic state of neural cells in the larval brain of Drosophila. The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that...

Kidney-synthesized erythropoietin is the main source for the hypoxia-induced increase in plasma erythropoietin in adult humans

Lundby, Anne-Kristine ; Keiser, Stefanie ; Siebenmann, Christoph ; Schäffer, Leonhard ; Lundby, Carsten

In: European Journal of Applied Physiology, 2014, vol. 114, no. 6, p. 1107-1111

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction

Rudnick, Gary ; Krämer, Reinhard ; Blakely, Randy ; Murphy, Dennis ; Verrey, Francois

In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 1, p. 25-42

Cardiovascular determinants of life span

Shi, Yi ; Camici, Giovanni ; Lüscher, Thomas

In: Pflügers Archiv - European Journal of Physiology, 2010, vol. 459, no. 2, p. 315-324