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Université de Fribourg

3D imaging of undissected optically cleared Anopheles stephensi mosquitoes and midguts infected with Plasmodium parasites

Niz, Mariana De ; Kehrer, Jessica ; Brancucci, Nicolas M. B. ; Moalli, Federica ; Reynaud, Emmanuel G. ; Stein, Jens V. ; Frischknecht, Friedrich

In: PLOS ONE, 2020, vol. 15, no. 9, p. e0238134

Malaria is a life-threatening disease, caused by Apicomplexan parasites of the Plasmodium genus. The Anopheles mosquito is necessary for the sexual replication of these parasites and for their transmission to vertebrate hosts, including humans. Imaging of the parasite within the insect vector has been attempted using multiple microscopy methods, most of which are hampered by the presence of...

Université de Fribourg

Parasite‐driven replacement of a sexual by a closely related asexual taxon in nature

Lohr, Jennifer N. ; Haag, Christoph R.

In: Ecology, 2020, vol. 101, no. 10, p. -

Asexual species are thought to suffer more from coevolving parasites than related sexuals. Yet a variety of studies do not find the patterns predicted by theory. Here, to shine light on this conundrum, we investigate one such case of an asexual advantage in the presence of parasites. We follow the frequency dynamics of sexual and asexual Daphnia pulex in a natural pond that was initially...

Université de Fribourg

Role of extracellular vesicles in cellular cross talk in malaria

Babatunde, Kehinde Adebayo ; Subramanian, Bibin Yesodha ; Ahouidi, Ambroise Dioum ; Murillo, Paola Martinez ; Walch, Michael

In: Frontiers in Immunology, 2020, vol. 11, p. -

Malaria infection caused by the Plasmodium species is a complex disease in which a fine balance between host and parasite factors determine the outcome of the disease. While in some individuals, the infection will trigger only a mild and uncomplicated disease, other individuals will develop severe complications and eventually die. Extracellular vesicles (EVs) secreted by infected red blood...