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Loss and revival of androgen receptor signaling in advanced prostate cancer

Formaggio, Nicolò ; Rubin, Mark A. ; Theurillat, Jean-Philippe

In: Oncogene, 2021, vol. 40, no. 7, p. 1205–1216

Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens have emerged and have been successfully i mplemented in clinical practice. That said, the stronger inhibition of the AR signaling axis has led in recent years to an increase of prostate cancers that de-differentiate...

Sharp neck injuries in suicidal intention

Biétry, Damien ; Exadaktylos, Aristomenis ; Müller, Thomas ; Zbären, Peter ; Caversaccio, Marco ; Arnold, Andreas

In: European Archives of Oto-Rhino-Laryngology, 2015, vol. 272, no. 12, p. 3825-3831

The 80-W KTP GreenLight laser vaporization of the prostate versus transurethral resection of the prostate (TURP): adjusted analysis of 5-year results of a prospective non-randomized bi-center study

Guo, Sanwei ; Müller, Georg ; Lehmann, Kurt ; Talimi, Scherwin ; Bonkat, Gernot ; Püschel, Heike ; Gasser, Thomas ; Bachmann, Alexander ; Rieken, Malte

In: Lasers in Medical Science, 2015, vol. 30, no. 3, p. 1147-1151

A novel prostate cell type-specific gene signature to interrogate prostate tumor differentiation status and monitor therapeutic response (running title: Phenotypic classification of prostate tumors)

Mapelli, Sarah N. ; Albino, Domenico ; Mello-Grand, Maurizia ; Shinde, Dheeraj ; Scimeca, Manuel ; Bonfiglio, Rita ; Bonanno, Elena ; Chiorino, Giovanna ; Garcia-Escudero, Ramon ; Catapano, Carlo V. ; Carbone, Giuseppina M.

In: Cancers, 2020, vol. 12, no. 1, p. 23 p

In this study, we extracted prostate cell-specific gene sets (metagenes) to define the epithelial differentiation status of prostate cancers and, using a deconvolution-based strategy, interrogated thousands of primary and metastatic tumors in public gene profiling datasets. We identified a subgroup of primary prostate tumors with low luminal epithelial enrichment (LumElow). LumElow tumors were...

SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination

Daddacha, Waaqo ; Koyen, Allyson E. ; Bastien, Amanda J. ; Head,Pamela Sara E. ; Dhere, Vishal R. ; Nabeta, Geraldine N. ; Connolly, Erin C. ; Werner, Erica ; Madden, Matthew Z. ; Daly, Michele B. ; Minten, Elizabeth V. ; Whelan, Donna R. ; Schlafstein, Ashley J. ; Zhang, Hui ; Anand, Roopesh ; Doronio, Christine ; Withers, Allison E. ; Shepard, Caitlin ; Sundaram, Ranjini K. ; Deng, Xingming ; Dynan, William S. ; Wang, Ya ; Bindra, Ranjit S. ; Cejka, Petr ; Rothenberg, Eli ; Doetsch, Paul W. ; Kim, Baek ; Yu, David S.

In: Cell reports, 2017, vol. 20, no. 8, p. 1921-1935

DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV- 1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We show that SAMHD1 has a dNTPase-independent function in promoting DNA end resection to facilitate...

The Mre11-Nbs1 interface is essential for viability and tumor suppression

Kim, Jun Hyun ; Grosbart, Malgorzata ; Anand, Roopesh ; Wyman, Claire ; Cejka, Petr ; Petrini, John H.J.

In: Cell reports, 2017, vol. 18, no. 2, p. 496-507

The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal levels. To delineate essential and non-essential Mre11 complex functions that are mediated by Nbs1, we used TALEN-based genome editing to derive Nbs1...

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Revandkar, Ajinkya ; Perciato, Maria Luna ; Toso, Alberto ; Alajati, Abdullah ; Chen, Jingjing ; Gerber, Hermeto ; Dimitrov, Mitko ; Rinaldi, Andrea ; Delaleu, Nicolas ; Pasquini, Emiliano ; D’Antuono, Rocco ; Pinton, Sandra ; Losa, Marco ; Gnetti, Letizia ; Arribas, Alberto ; Fraering, Patrick ; Bertoni, Francesco ; Nepveu, Alain ; Andrea Alimonti

In: Nature communications, 2016, vol. 7, p. 13719

Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive. Moreover, preclinical evidence of the therapeutic efficacy of NOTCH inhibitors in prostate cancer is lacking. Here, we provide evidence that PTEN loss in prostate tumours ...

Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity

Toso, Alberto ; Revandkar, Ajinkya ; Di Mitri, Diletta ; Guccini, Ilaria ; Proietti, Michele ; Sarti, Manuela ; Pinton, Sandra ; Zhang, Jiangwen ; Kalathur, Madhuri ; Civenni, Gianluca ; Jarrossay, David ; Montani, Erica ; Marini, Camilla ; Garcia-Escudero, Ramon ; Scanziani, Eugenio ; Grassi, Fabio ; Pandolfi, Pier Paolo ; Catapano, Carlo V. ; Alimonti, Andrea

In: Cell reports, 2014, vol. 9, no. 1, p. 75-89

PET/MRI and PET/CT in follow-up of head and neck cancer patients

Queiroz, Marcelo ; Hüllner, Martin ; Kuhn, Felix ; Huber, Gerhardt ; Meerwein, Christian ; Kollias, Spyros ; von Schulthess, Gustav ; Veit-Haibach, Patrick

In: European Journal of Nuclear Medicine and Molecular Imaging, 2014, vol. 41, no. 6, p. 1066-1075

Individualized IMRT treatment approach for cervical lymph node metastases of unknown primary = Individualisierter IMRT-Bestrahlungsansatz bei zervikalen Lymphknotenmetastasen mit unbekanntem Primärtumor

Janssen, S. ; Glanzmann, C. ; Huber, G. ; Studer, G.

In: Strahlentherapie und Onkologie, ///-