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Autoimmune hepatitis : serum autoantibodies in clinical practice

Terziroli Beretta-Piccoli, Benedetta ; Mieli Vergani, Giorgina ; Vergani, Diego

In: Clinical reviews in allergy & immunology, 2021, p. 14

Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to dedicated guidelines issued by the International Autoimmune Hepatitis Group. They also allow the distinction between type 1 AIH, characterized by positive anti-nuclear and/or anti-smooth muscle antibody, and type 2 AIH, characterized by positive...

Waddlia chondrophila, a Chlamydia-related bacterium, has a negative impact on human spermatozoa

Baud, D. ; Vulliemoz, N. ; Ammerdorffer, A. ; Gyger, J. ; Greub, G. ; Castella, V. ; Stojanov, M.

In: Human Reproduction, 2018, vol. 33, no. 1, p. 3-10

Pathogenesis of adult-onset Still's disease: new insights from the juvenile counterpart

Jamilloux, Yvan ; Gerfaud-Valentin, Mathieu ; Martinon, Fabio ; Belot, Alexandre ; Henry, Thomas ; Sève, Pascal

In: Immunologic Research, 2015, vol. 61, no. 1-2, p. 53-62

The potential use of microcalorimetry in rapid differentiation between septic arthritis and other causes of arthritis

Yusuf, E. ; Hügle, T. ; Daikeler, T. ; Voide, C. ; Borens, O. ; Trampuz, A.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 3, p. 461-465

Detection of IgM/IgG antibodies to the novel coronavirus (SARS-CoV-2) in cardiology caregivers using a qualitative detection kit

Schukraft, Sara ; Fellay, Benot ; Togni, Mario ; Magnin, Jean-Luc ; Nordmann, Patrice ; Cook, Stphane

In: Cardiovascular Medicine, 2020, p. -

Serum immunoglobulin a cross-strain blockade of human noroviruses

Lindesmith, Lisa C. ; Beltramello, Martina ; Swanstrom, Jesica ; Jones, Taylor A. ; Corti, Davide ; Lanzavecchia, Antonio ; Baric, Ralph S.

In: Open forum infectious diseases, 2015, vol. 2, no. 3, p. ofv084

Background: Human noroviruses are the leading cause of acute viral gastroenteritis, justifying vaccine development despite a limited understanding of strain immunity. After genogroup I (GI).1 norovirus infection and immunization, blockade antibody titers to multiple virus-like particles (VLPs) increase, suggesting that GI cross-protection may occur. Methods: Immunoglobulin (Ig)A was purified...

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone

Pickett, Julie E. ; Thompson, John M. ; Sadowska, Agnieszka ; Tkaczyk, Christine ; Sellman, Bret R. ; Minola, Andrea ; Corti, Davide ; Lanzavecchia, Antonio ; Miller, Lloyd S. ; Thorek, Daniel LJ

In: Bone research, 2018, vol. 6, p. 13

Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody (mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid (LTA). Specificity and affinity were assessed in...

Redox-mediated mechanisms fuel monocyte responses to CXCL12/HMGB1 in active rheumatoid arthritis

Cecchinato, Valentina ; D'Agostino, Gianluca ; Raeli, Lorenzo ; Nerviani, Alessandra ; Schiraldi, Milena ; Danelon, Gabriela ; Manzo, Antonio ; Thelen, Marcus ; Ciurea, Adrian ; Bianchi, Marco E. ; Rubartelli, Anna ; Pitzalis, Costantino ; Uguccioni, Mariagrazia

In: Frontiers in immunology, 2018, vol. 9, p. 2118

Chemokine synergy-inducing molecules are emerging as regulating factors in cell migration. The alarmin HMGB1, in its reduced form, can complex with CXCL12 enhancing its activity on monocytes via the chemokine receptor CXCR4, while the form containing a disulfide bond, by binding to TLR2 or TLR4, initiates a cascade of events leading to production of cytokines and chemokines. So far, the...

SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts

Engler, Anna ; Niederer, Fabienne ; Klein, Kerstin ; Gay, Renate ; Kyburz, Diego ; Camici, Giovanni ; Gay, Steffen ; Ospelt, Caroline

In: Journal of Molecular Medicine, 2014, vol. 92, no. 7, p. 757-767

Gram and acridine orange staining for diagnosis of septic arthritis in different patient populations

Cunningham, Gregory ; Seghrouchni, Khalid ; Ruffieux, Etienne ; Vaudaux, Pierre ; Gayet-Ageron, Angèle ; Cherkaoui, Abdessalam ; Godinho, Eduardo ; Lew, Daniel ; Hoffmeyer, Pierre ; Uçkay, Ilker

In: International Orthopaedics, 2014, vol. 38, no. 6, p. 1283-1290