In: Seminars in Immunopathology, 2015, vol. 37, no. 5, p. 519-528
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In: Bioinformatics, 2016, vol. 32, no. 13, p. 1990-2000
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In: Current Biology, 2020, vol. 30, no. 19, p. 3775-3787.e7
Sphingolipids play important roles in physiology and cell biology, but a systematic examination of their functions is lacking. We performed a genome-wide CRISPRi screen in sphingolipid-depleted human cells and identified hypersensitive mutants in genes of membrane trafficking and lipid biosynthesis, including ether lipid synthesis. Systematic lipidomic analysis showed a coordinate regulation...
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In: New Phytologist, 2019, vol. 223, no. 4, p. 2076–2089
The genomic architecture of functionally important traits is key to understanding the maintenance of reproductive barriers and trait differences when divergent populations or species hybridize. We conducted a genome-wide association study (GWAS) to study trait architecture in natural hybrids of two ecologically divergent Populus species. We genotyped 472 seedlings from a natural hybrid zone...
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In: PLOS Genetics, 2019, vol. 15, no. 7, p. e1008269
Development of eye tissue is initiated by a conserved set of transcription factors termed retinal determination network (RDN). In the fruit fly Drosophila melanogaster, the zinc-finger transcription factor Glass acts directly downstream of the RDN to control identity of photoreceptor as well as non-photoreceptor cells. Tight control of spatial and temporal gene expression is a critical...
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In: Plos one, 2011, vol. 6, no. 6, p. e21386
FoxP3+ Treg cells are believed to play a role in the occurrence of autoimmunity and in the determination of clinical recurrences. Contradictory reports are, however, available describing frequency and function of Treg cells during autoimmune diseases. We examined, by both polychromatic flow cytometry, and real-time RT-PCR, several Treg markers in peripheral blood mononuclear cells from...
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In: Brain Topography, 2014, vol. 27, no. 2, p. 318-327
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In: International Journal of Obesity, 2018, vol. 42, no. 8, p. 1395–1405
As yet, genome-wide association studies (GWAS) have not added much to our understanding of the mechanisms of body weight control and of the etiology of obesity. This shortcoming is widely attributed to the complexity of the issues. The appeal of this explanation notwithstanding, we surmise that (i) an oversimplification of the phenotype (namely by the use of crude anthropometric traits) and...
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In: Clinical Autonomic Research, 2005, vol. 15, no. 6, p. 420-420
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In: Journal of Neurology, 2004, vol. 251, no. 1, p. 105-107
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