In: Journal of the American Medical Informatics Association, 2017, vol. 24, no. 4, p. 799-805
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In: Systematic Biology, 2017, vol. 66, no. 5, p. 769-785
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In: Brain, 2016, vol. 139, no. 6, p. 1855-1861
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In: American Journal of Health-System Pharmacy, 2017, vol. 74, no. 22, p. 1879-1886
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In: Bioinformatics, 2017, vol. 33, no. 21, p. 3454-3460
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In: Human Molecular Genetics, 2018, vol. 27, no. 4, p. 732-741
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In: Evolution Letters, 2020, vol. 4, no. 2, p. 94–108
Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct...
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In: Evolution, 2019, vol. 73, no. 9, p. 1774–1792
A fundamental aim of adaptation genomics is to identify polymorphisms that underpin variation in fitness traits. In Drosophila melanogaster, latitudinal life‐history clines exist on multiple continents and make an excellent system for dissecting the genetics of adaptation. We have previously identified numerous clinal single‐nucleotide polymorphism in insulin/insulin‐like growth factor...
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In: Plos one, 2011, vol. 6, no. 10, p. e26133
Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost completely unexplored. To examine the role of the activation-induced miRNA miR-221 in mouse mast cells, we developed robust lentiviral systems for miRNA overexpression and...
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In: The European Physical Journal Special Topics, 2014, vol. 223, no. 11, p. 2285-2295
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