Università della Svizzera italiana

Intestinal microbiota drives cholestasis-induced specific hepatic gene expression patterns

Juanola, Oriol ; Hassan, Mohsin ; Kumar, Pavitra ; Yilmaz, Bahtiyar ; Keller, Irene ; Simillion, Cédric ; Engelmann, Cornelius ; Tacke, Frank ; Dufour, Jean-François ; De Gottardi, Andrea ; Moghadamrad, Sheida

In: Gut microbes, 2021, vol. 13, no. 1, p. 20

Intestinal microbiota regulates multiple host metabolic and immunological processes. Consequently, any difference in its qualitative and quantitative composition is susceptible to exert significant effects, in particular along the gut-liver axis. Indeed, recent findings suggest that such changes modulate the severity and the evolution of a wide spectrum of hepatobiliary disorders. However, the...

Université de Fribourg

Typical imaging finding of hepatic infections: a pictorial essay

Malekzadeh, Sonaz ; Widmer, Lucien ; Salahshour, Faezeh ; Egger, Bernhard ; Ronot, Maxime ; Thoeny, Harriet C.

In: Abdominal Radiology, 2020, p. -

Hepatic infections are frequent in clinical practice. Although epidemiological, clinical and laboratory data may suggest hepatic infection in certain cases, imaging is nearly always necessary to confirm the diagnosis, assess disease extension and its complications, evaluate the response to treatment, and sometimes to make differential diagnoses such as malignancies. Ultrasound (US) is usually...

Université de Fribourg

Platelet interactions with liver sinusoidal endothelial cells and hepatic stellate cells lead to hepatocyte proliferation

Meyer, Jeremy ; Balaphas, Alexandre ; Fontana, Pierre ; Morel, Philippe ; Robson, Simon C. ; Sadoul, Karin ; Gonelle-Gispert, Carmen ; Bühler, Léo

In: Cells, 2020, vol. 9, no. 5, p. 1243

Background: Platelets were postulated to constitute the trigger of liver regeneration. The aim of this study was to dissect the cellular interactions between the various liver cells involved in liver regeneration and to clarify the role of platelets. (2) Methods: Primary mouse liver sinusoidal endothelial cells (LSECs) were co-incubated with increasing numbers of resting platelets, activated...