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Université de Fribourg

The Role of Clusters in the Global Innovation Strategy of MNEs : Theoretical Foundations and Evidence from the Basel Pharmaceutical Cluster

Gugler, Philippe ; Keller, Michael ; Tinguely, Xavier

In: Competitiveness Review, 2015, vol. 25, no. 3, p. 324-340

Purpose – This paper aims to focus on the role of clusters as home and host country- specific advantages for multinational enterprises (“MNEs”) in the organization of their internal and external networks to optimize the diffusion and generation of new knowledge. Strategic asset-seeking investment has been a major driver of the internalization of innovation activities performed by MNEs...

Consortium of Swiss Academic Libraries

The authors' reply: Population mixing and childhood leukaemia

Lupatsch, Judith ; Egger, Matthias ; Kuehni, Claudia ; Spycher, Ben

In: European Journal of Epidemiology, 2015, vol. 30, no. 12, p. 1333-1334

Université de Fribourg

Are integrins still practicable targets for anti-cancer therapy?

Alday-Parejo, Begoña ; Stupp, Roger ; Rüegg, Curzio

In: Cancers, 2019, vol. 11, no. 7, p. 978

Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...

Université de Fribourg

Patenting government funded innovations as a strategy to increase budget for academic vaccine R&D

Songane, Mario

(Working Papers SES ; 509)

Vaccine development is a lengthy, expensive and risky venture, with the research and development (R&D) process costing billions of dollars. The pre-clinical stage of vaccine R&D is largely performed by academic research institutions, then continued by the pharmaceutical industry though licensing agreements, taking the most promising candidates to the clinical testing stage. Governments play a...

Université de Fribourg

The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis

Ahmad, Akbar ; Vieira, Juliana de Camargo ; Mello, Aline Haas de ; Lima, Thais Martins de ; Ariga, Suely Kubo ; Barbeiro, Denise Frediani ; Barbeiro, Hermes Vieira ; Szczesny, Bartosz ; Törö, Gábor ; Druzhyna, Nadiya ; B.Randi, Elisa ; Marcatti, Michela ; Toliver-Kinsky, Tracy ; Kiss, András ; Liaudet, Lucas ; Salomao, Reinaldo ; Soriano, Francisco Garcia ; Szabo, Csaba

In: Pharmacological Research, 2019, vol. 145, p. 104263

Poly(ADP-ribose) polymerase (PARP) is involved in the pathogenesis of cell dysfunction, inflammation and organ failure during septic shock. The goal of the current study was to investigate the efficacy and safety of the clinically approved PARP inhibitor olaparib in experimental models of oxidative stress in vitro and in sepsis in vivo. In mice subjected to cecal ligation and puncture (CLP)...