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Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates

Denervaud-Tendon, Valérie ; Poirel, Laurent ; Connolly, Lynn E. ; Krause, Kevin M. ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 10, p. 2787-2791

CSF lactate for accurate diagnosis of community-acquired bacterial meningitis

Giulieri, S. ; Chapuis-Taillard, C. ; Jaton, K. ; Cometta, A. ; Chuard, C. ; Hugli, O. ; Du Pasquier, R. ; Bille, J. ; Meylan, P. ; Manuel, O. ; Marchetti, O.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 10, p. 2049-2055

Impact of round-the-clock CSF Gram stain on empirical therapy for suspected central nervous system infections

Tissot, F. ; Prod'hom, G. ; Manuel, O. ; Greub, G.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 9, p. 1849-1857

Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies

Rieben, Carole ; Segna, Daniel ; da Costa, Bruno R. ; Collet, Tinh-Hai ; Chaker, Layal ; Aubert, Carole E. ; Baumgartner, Christine ; Almeida, Osvaldo P. ; Hogervorst, Eef ; Trompet, Stella ; Masaki, Kamal ; Mooijaart, Simon P. ; Gussekloo, Jacobijn ; Peeters, Robin P. ; Bauer, Douglas C. ; Aujesky, Drahomir ; Rodondi, Nicolas

In: The Journal of Clinical Endocrinology & Metabolism, 2016, vol. 101, no. 12, p. 4945-4954

Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial

Blum, Manuel R. ; Gencer, Baris ; Adam, Luise ; Feller, Martin ; Collet, Tinh-Hai ; da Costa, Bruno R. ; Moutzouri, Elisavet ; Dopheide, Jörn ; Depairon, Michèle ; Sykiotis, Gerasimos P. ; Kearney, Patricia ; Gussekloo, Jacobijn ; Westendorp, Rudi ; Stott, David J. ; Bauer, Douglas C. ; Rodondi, Nicolas

In: The Journal of Clinical Endocrinology & Metabolism, 2018, vol. 103, no. 8, p. 2988-2997

Postmortem quantitative 1.5-T MRI for the differentiation and characterization of serous fluids, blood, CSF, and putrefied CSF

Zech, Wolf-Dieter ; Schwendener, Nicole ; Persson, Anders ; Warntjes, Marcel ; Riva, Fabiano ; Schuster, Frederick ; Jackowski, Christian

In: International Journal of Legal Medicine, 2015, vol. 129, no. 5, p. 1127-1136

Conserved functions of ether lipids and sphingolipids in the early secretory pathway

Jiménez-Rojo, Noemi ; Leonetti, Manuel D. ; Zoni, Valeria ; Colom, Adai ; Feng, Suihan ; Iyengar, Namrata R. ; Matile, Stefan ; Roux, Aurélien ; Vanni, Stefano ; Weissman, Jonathan S. ; Riezman, Howard

In: Current Biology, 2020, vol. 30, no. 19, p. 3775-3787.e7

Sphingolipids play important roles in physiology and cell biology, but a systematic examination of their functions is lacking. We performed a genome-wide CRISPRi screen in sphingolipid-depleted human cells and identified hypersensitive mutants in genes of membrane trafficking and lipid biosynthesis, including ether lipid synthesis. Systematic lipidomic analysis showed a coordinate regulation...

Multilevel regulation of the glass locus during Drosophila eye development

Fritsch, Cornelia ; Bernardo-Garcia, F. Javier ; Humberg, Tim-Henning ; Mishra, Abhishek Kumar ; Miellet, Sara ; Almeida, Silvia ; Frochaux, Michael V. ; Deplancke, Bart ; Huber, Armin ; Sprecher, Simon G.

In: PLOS Genetics, 2019, vol. 15, no. 7, p. e1008269

Development of eye tissue is initiated by a conserved set of transcription factors termed retinal determination network (RDN). In the fruit fly Drosophila melanogaster, the zinc-finger transcription factor Glass acts directly downstream of the RDN to control identity of photoreceptor as well as non-photoreceptor cells. Tight control of spatial and temporal gene expression is a critical...

Sex and age dependencies of aqueductal cerebrospinal fluid dynamics parameters in healthy subjects

Sartoretti, Thomas ; Wyss, Michael ; Sartoretti, Elisabeth ; Reischauer, Carolin ; Hainc, Nicolin ; Graf, Nicole ; Binkert, Christoph ; Najafi, Arash ; Sartoretti-Schefer, Sabine

In: Frontiers in Aging Neuroscience, 2019, vol. 11, p. 199

Objectives: To assess the influence of age and sex on 10 cerebrospinal fluid (CSF) flow dynamics parameters measured with an MR phase contrast (PC) sequence within the cerebral aqueduct at the level of the intercollicular sulcus.Materials and Methods: 128 healthy subjects (66 female subjects with a mean age of 52.9 years and 62 male subjects with a mean age of 51.8 years) with a normal Evans...

The neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells

Gupta, Sandeep ; Gach, Johannes S. ; Becerra, Juan C. ; Phan, Tran B. ; Pudney, Jeffrey ; Moldoveanu, Zina ; Joseph, Sarah B. ; Landucci, Gary ; Supnet, Medalyn Jude ; Ping, Li-Hua ; Corti, Davide ; Moldt, Brian ; Hel, Zdenek ; Lanzavecchia, Antonio ; Ruprecht, Ruth M. ; Burton, Dennis R. ; Mestecky, Jiri ; Anderson, Deborah J. ; Forthal, Donald N.

In: Plos pathogens, 2013, vol. 9, no. 11, p. e1003776

The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody. We found that the combination of acidic pH and Env- specific IgG, including that from cervicovaginal and seminal fluids of HIV-1-infected individuals, augmented transcytosis...